Document Detail


Prevalence of small-bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy.
MedLine Citation:
PMID:  25209657     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The aim was to determine the prevalence of small-bowel neoplasia in asymptomatic patients with Lynch syndrome (LS) by video capsule endoscopy (VCE).
DESIGN: After obtaining informed consent, asymptomatic proven gene mutation carriers aged 35-70 years were included in this prospective multicentre study in the Netherlands. Patients with previous small-bowel surgery were excluded. After bowel preparation, VCE was performed. The videos were read by two independent investigators. If significant lesions were detected, an endoscopic procedure was subsequently performed to obtain histology and, if possible, remove the lesion.
RESULTS: In total, 200 patients (mean age 50 years (range 35-69), M/F 88/112), with proven mutations were included. These concerned MLH1 (n=50), MSH2 (n=68), MSH6 (n=76), PMS2 (n=3) and Epcam (n=3) mutation carriers. In 95% of the procedures, caecal visualisation was achieved. Small-bowel neoplasia was detected in two patients: one adenocarcinoma (TisN0Mx) and one adenoma, both located in the duodenum. In another patient, a duodenal cancer (T2N0Mx) was diagnosed 7 months after a negative VCE. This was considered a lesion missed by VCE. All three neoplastic lesions were within reach of a conventional gastroduodenoscope. All patients with neoplasia were men, over 50 years of age and without a family history of small-bowel cancer.
CONCLUSIONS: The prevalence of small-bowel neoplasia in asymptomatic patients with LS was 1.5%. All neoplastic lesions were located in the duodenum and within reach of conventional gastroduodenoscopy. Although VCE has the potential to detect these neoplastic lesions, small-bowel neoplasia may be missed.
TRIAL REGISTRATION NUMBER: NCT00898768.
Authors:
Jasmijn F Haanstra; Abdul Al-Toma; Evelien Dekker; Steven A L W Vanhoutvin; Fokko M Nagengast; Elisabeth M Mathus-Vliegen; Monique E van Leerdam; Wouter H de Vos Tot Nederveen Cappel; Silvia Sanduleanu; Roeland A Veenendaal; Annemieke Cats; Hans F A Vasen; Jan H Kleibeuker; Jan J Koornstra
Related Documents :
25313987 - Prognostic significance of weight changes in parkinson's disease: the park-weight pheno...
25225187 - Impact of patient positioning on lung ultrasound findings in acute heart failure.
25415487 - Is atlantoaxial instability the cause of chiari malformation? outcome analysis of 65 pa...
25239317 - Extended use of diaphragm pacing in patients with unilateral or bilateral diaphragm dys...
14748567 - Laminoplasty for cervical myelopathy caused by subaxial lesions in rheumatoid arthritis.
17137147 - Patients' attitudes towards mydriasis for diabetic eye disease screening.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-10
Journal Detail:
Title:  Gut     Volume:  -     ISSN:  1468-3288     ISO Abbreviation:  Gut     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associat...
Next Document:  'I saw Santa drinking soda!' Advertising and children's food preferences.