Document Detail

Prevalence and significance of an isolated long QT interval in elite athletes.
MedLine Citation:
PMID:  17947213     Owner:  NLM     Status:  MEDLINE    
AIMS: Identification of a prolonged, corrected QT (QTc) interval in athletes may be a recommendation for disqualification from competitive sports. However, the prevalence and diagnostic significance of an isolated prolonged QTc in asymptomatic athletes without familial disease is unknown. METHODS AND RESULTS: Between 1996 and 2006, 2000 elite athletes (mean age, 20.2 years) underwent 12-lead ECG and 2-D echocardiography. The QT interval was corrected for heart rate (QTc). Athletes with QTc > 460 ms underwent 48 h Holter monitor and an exercise stress test. All athletes with a prolonged QTc interval were offered genetic testing and first-degree relatives were invited for ECG. The QTc was prolonged in seven (0.4%) athletes ranging from 460 to 570 ms. Three athletes had a QTc value of >500 ms and all exhibited one of: paradoxical prolongation of QTc during exercise, a confirmatory genetic mutation, or prolonged QTc in a first-degree relative. In contrast, none of the athletes with a QTc value of <500 ms had any other features to indicate long QT syndrome (LQTS). CONCLUSION: The prevalence of prolonged QTc in elite athletes is 0.4%. A QTc of >500 ms is highly suggestive of LQTS. A QTc of <500 ms in the absence of symptoms or familial disease is unlikely to represent LQTS in elite athletes.
Sandeep Basavarajaiah; Matthew Wilson; Gregory Whyte; Ajay Shah; Elijah Behr; Sanjay Sharma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-18
Journal Detail:
Title:  European heart journal     Volume:  28     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-04-10     Revised Date:  2008-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  2944-9     Citation Subset:  IM    
University Hospital Lewisham/King's College Hospital, London SE5 9RS, UK.
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MeSH Terms
Electrocardiography / methods
Exercise Test
Heart Rate / physiology*
Long QT Syndrome / diagnosis*,  epidemiology,  genetics
Sports / physiology*
Comment In:
Eur Heart J. 2007 Dec;28(23):2825-6   [PMID:  17967824 ]
Eur Heart J. 2008 May;29(9):1210-1; author reply 1211   [PMID:  18411211 ]

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