| Prevalence and severity of coronary artery disease in diabetic patients with aortic valve calcification. | |
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MedLine Citation:
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PMID: 21446377 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: Aortic valve calcification (AVC) is common in the elderly and associated with increased cardiovascular mortality, while diabetes is one of the confirmed risk factors for coronary artery disease (CAD). In this study, we aimed to evaluate the prevalence and severity of CAD in type-2 diabetic patients with AVC. METHODS: From June to December in 2007, a total of 325 consecutive patients with chest pain or chest distress were admitted for coronary angiography. The severity of CAD was evaluated by the Gensini score and the number of stenosed vessels. All patients underwent transthoracic echocardiography for detecting AVC. RESULTS: Compared with the patients without diabetes (n = 221), the type-2 diabetic patients (n = 104) had a similar prevalence of CAD (66.5% vs. 72.1%, P = 0.312). Further classified by the presence of AVC, patients with AVC had a higher prevalence of CAD, average Gensini score and the number of stenosed vessels, both in the group with and without diabetes. It was also demonstrated that the odds ratio (OR) of AVC for CAD in the diabetic patients was higher than in the non-diabetic ones (3.405 vs 2.515) after chi-square analysis (single-variable). However, at multivariable logistic regression analysis for CAD, the OR of AVC was 3.757 (P = 0.03) in diabetic group, while it did not achieve statistical significance in the non-diabetic group (OR = 2.130, P= 0.074). CONCLUSIONS: Type-2 diabetic patients with AVC had a higher prevalence of and more severe CAD. |
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Authors:
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Zhang-wei Chen; Ju-ying Qian; Ying Jian; Lei Ge; Xue-bo Liu; Xian-hong Shu; Junbo Ge |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta cardiologica Volume: 66 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: Belgium |
Other Details:
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Languages: eng Pagination: 15-20 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P.R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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