Document Detail


Prevalence of sensitivity to sulfiting agents in asthmatic patients.
MedLine Citation:
PMID:  3535492     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ingestion of sulfiting agents can induce wheezing in some asthmatic patients. However, neither the prevalence of sulfite sensitivity nor the clinical characteristics of the affected asthmatic population are known. In a prospective single-blind screening study, 120 non-steroid-dependent and 83 steroid-dependent asthmatic patients underwent challenge with oral capsules of potassium metabisulfite. Five non-steroid-dependent and 16 steroid-dependent asthmatic patients experienced a greater than 20 percent reduction in their one-second forced expiratory volume within 30 minutes following the oral challenge. Twelve of these sulfite reactors were rechallenged with metabisulfite capsules in a double-blind protocol. Under these conditions, only three of seven steroid-dependent patients had a positive response. Moreover, only one of five non-steroid-dependent patients had a response to double-blind challenge. On the basis of this challenge study, the best estimate of the prevalence of sulfite sensitivity in the asthmatic patients studied is 3.9 percent. This population, however, contained a larger number of steroid-dependent asthmatic patients than would be found in the general asthmatic population. It is concluded, therefore, that the prevalence of sulfite sensitivity in the asthmatic population as a whole would be less than 3.9 percent and that steroid-dependent asthmatic patients are most at risk.
Authors:
R K Bush; S L Taylor; K Holden; J A Nordlee; W W Busse
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of medicine     Volume:  81     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-12-04     Completed Date:  1986-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  816-20     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / drug therapy,  immunology*
Clinical Trials as Topic
Double-Blind Method
Female
Forced Expiratory Volume
Humans
Hypersensitivity / etiology*
Male
Middle Aged
Prospective Studies
Random Allocation
Risk
Steroids / therapeutic use
Sulfites / adverse effects*
Chemical
Reg. No./Substance:
0/Steroids; 0/Sulfites

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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