Document Detail

Prevalence and risk factors for urolithiasis in primary gout: is a reappraisal needed?
MedLine Citation:
PMID:  16265701     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the prevalence and risk factors for urolithiasis in primary gout. METHODS: One hundred forty patients with primary gout were studied. Urolithiasis was defined as a history of urolithiasis, or nephrolithiasis detected via ultrasonography in patients with no previous record of urolithiasis. Patient age, duration of gout, presence of tophi, obesity, alcoholism, high blood pressure, diabetes, hyperlipidemia, family history of urolithiasis, daily urine output, uricemia, urine pH, FeNa, FeUrate, urine pH/FeUrate index, and daily urine excretion of urate, sodium, calcium and potassium were compared between lithiasic and non-lithiasic subjects. RESULTS: Fifty-five (39%; 95% CI 31-47) patients had urolithiasis, of which 37 (26%) were diagnosed by clinical history and 18 (13%) by ultrasonography. Patients with a silent kidney stone diagnosed by ultrasound tended to have shorter evolution of gout. Aside from urinary H+ ion concentration (lithiasic subjects 5.17 +/- 3.9 microM/l; non-lithiasic subjects 3.80 +/- 3.01 microM/l; p = 0.02), no difference was found between lithiasic and non-lithiasic subjects for the other variables studied. CONCLUSION: Ultrasonography increased the probability of diagnosing urolithiasis by 50%, meaning the prevalence of urolithiasis in gout is likely higher than previously reported. A higher urinary H+ ion concentration was the only variable associated with urolithiasis. Due to advances in diagnosis of gout and urolithiasis, as well as biochemical assays, the prevalence and risk factors for urolithiasis in gout require reassessment.
José Alvarez-Nemegyei; Martha Medina-Escobedo; Salha Villanueva-Jorge; Janitzia Vazquez-Mellado
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  32     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-02     Completed Date:  2005-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  2189-91     Citation Subset:  IM    
Unidad de Investigación en Epidemiología Clínica, HE CMN Ignacio García Tellez, Instituto Mexicano del Seguro Social, Mérida, Yucatán, México.
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MeSH Terms
Gout / epidemiology*
Mexico / epidemiology
Middle Aged
Risk Factors
Urinary Calculi / epidemiology*,  ultrasonography,  urine
Reg. No./Substance:

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