| Prevalence and risk factors of syndrome Z in urban Indians. | |
| | |
MedLine Citation:
|
PMID: 20472499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Syndrome Z is defined as the co-occurrence of obstructive sleep apnea (OSA) and metabolic syndrome. There is a paucity of information on the magnitude of syndrome Z in the community and the factors associated with it. METHODS: We conducted a two-stage, cross-sectional, community-based study in four different socioeconomic zones of the South Delhi district, India, from April 2005 through June 2007. In stage 1, a systematic random sample of subjects of either gender aged 30-65 years were administered a questionnaire by door-to-door survey. Subjects that responded were classified as habitual and non-habitual snorers. In stage 2, all the habitual and 10% of randomly selected non-habitual snorers were invited for overnight polysomnography and evaluation for metabolic syndrome. The National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) criteria were used to define metabolic syndrome. RESULTS: Of the 2860 subjects approached, 2505 (88%) completed stage 1; 452 (18%) were habitual snorers. In stage 2, OSA (defined as apnea-hypopnea index > or =5) was observed in 94 (32.4%) of 290 habitual snorers and 3 (4%) of 75 non-habitual snorers. Seventy (77%) of the 91 habitual snorers with OSA also had metabolic syndrome; none of the non-habitual snorers with OSA had metabolic syndrome. The estimated population prevalence of metabolic syndrome was 43% [95% CI: (41.0-44.9%)] and syndrome Z was 4.5% (95% CI: 3.7-5.3). On multivariable analysis, age [OR: 1.05 (1.00-1.09)], male gender [OR: 5.64 (2.06-15.49)], percent body fat [OR: 1.08 (1.04-1.13)] and DeltaSaO(2) (%) (defined as the difference between baseline and minimum SaO(2) during overnight sleep study) [OR: 5.80 (2.36-14.26), 17.70 (5.97-52.17) and 57.1 (19.12-170.40) for 10-20%, 20-30% and >30% reduction respectively as compared to <10% reduction] were independently associated with syndrome Z. CONCLUSIONS: To the best of our knowledge, this is the first population-based study on the prevalence and risk factors of syndrome Z, and it reveals that a considerable proportion of community-dwelling northern Indian adults have syndrome Z. Age, male gender, percent body fat and severity of nocturnal desaturation were independent risk factors for syndrome Z. |
| | |
Authors:
|
Surendra K Sharma; Emmadi V Reddy; Abhishek Sharma; Tamilarasu Kadhiravan; Hridesh K Mishra; Vishnubhatla Sreenivas; Hemant K Mishra; Ramakrishnan Lakshmy |
Related Documents
:
|
6891369 - X-linked leigh's syndrome. 12905569 - Metabolic syndrome & obesity: co-epidemics could overwhelm home health care. 19900159 - Metabolic syndrome in obese children and adolescents: dichotomous or continuous? 16939679 - Metabolic syndrome in children and adolescents. 18431609 - Bariatric surgery outcomes in morbidly obese with the metabolic syndrome at us academic... 16958679 - In vivo imaging of hepatic fatty acid metabolism in patients with non-alcoholic steatoh... 22607989 - Schmallenberg virus in calf born at term with porencephaly, belgium. 23131889 - Drugs associated with restless legs syndrome: a case/noncase study in the french pharma... 8950329 - Xyy syndrome in children with acute lymphoblastic leukemia. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-15 |
Journal Detail:
|
Title: Sleep medicine Volume: 11 ISSN: 1878-5506 ISO Abbreviation: Sleep Med. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-31 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100898759 Medline TA: Sleep Med Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 562-8 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. surensk@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue Adult Aged Body Composition Comorbidity Cross-Sectional Studies Developing Countries* Female Health Surveys Humans India Male Metabolic Syndrome X / epidemiology*, ethnology* Middle Aged Oxygen / blood Risk Factors Sleep Apnea, Obstructive / epidemiology*, ethnology* Snoring / epidemiology, ethnology Socioeconomic Factors Syndrome Urban Population / statistics & numerical data* |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of sildenafil on sleep respiratory parameters and heart rate variability in obstructive s...
Next Document: Verification of the efficiency of chemical disinfection and sanitation measures in in-building distr...