Document Detail


Prevalence of risk factors for statin-induced myopathy in rheumatoid arthritis patients.
MedLine Citation:
PMID:  19642078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Statins are widely prescribed in patients with rheumatoid arthritis (RA). Although statins offer overwhelming cardiovascular benefits, their use can be associated with the development of a statin-induced myopathy. Several factors increase the risk of developing statin-induced myopathy, including the single nucleotide polymorphism (SNP) rs4149056, located within the gene encoding solute carrier organic anion transporter (SLCO1B1). We aimed to identify the frequency of risk factors for statin-induced myopathy and establish whether the rs4149056 genotype is more prevalent in RA.
METHODS: A total of 396 RA patients and 438 non-RA controls were studied. DNA samples were obtained from all patients. The SNP rs4149056 was identified using real-time polymerase chain reaction and melting curve analysis. Genotypic and allelic frequencies were calculated using the chi-squared test.
RESULTS: Almost 80% of RA patients had one or more risk factor (range 1-5) for the development of statin-induced myopathy. Of the 74 RA patients treated with statins, 90% had one or more (range 1-4) risk factors. No differences in genotype or allelic frequencies were observed between RA patients and controls.
CONCLUSIONS: RA patients harbour multiple risk factors for statin-induced myopathy. However, the frequency of the rs4149056 genotypes does not differ according to the presence of RA. Despite this, no cases of statin-induced myopathy were observed in this cohort over a period of four years of follow-up. Thus, we conclude that statin use among RA patients is probably safe, but large-scale prospective studies are needed to confirm this. In the meantime, it may be good practice systematically to consider and record myopathy risk factors in these patients.
Authors:
Tracey E Toms; Jacqueline P Smith; Vasileios F Panoulas; Karen M J Douglas; Athanasios N Saratzis; George D Kitas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Musculoskeletal care     Volume:  8     ISSN:  1557-0681     ISO Abbreviation:  Musculoskeletal Care     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-07-21     Revised Date:  2011-12-01    
Medline Journal Info:
Nlm Unique ID:  101181344     Medline TA:  Musculoskeletal Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  2-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 John Wiley & Sons, Ltd.
Affiliation:
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / chemically induced,  complications*,  genetics*
DNA / genetics
Gene Frequency
Genotype
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
Membrane Proteins
Muscular Diseases / chemically induced*,  complications,  genetics
Organic Anion Transporters / genetics*
Polymorphism, Single Nucleotide*
Prevalence
Risk
Risk Factors
Grant Support
ID/Acronym/Agency:
17682//Arthritis Research UK; 18848//Arthritis Research UK
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/LST1 protein, human; 0/Membrane Proteins; 0/Organic Anion Transporters; 0/SLCO1B1 protein, human; 9007-49-2/DNA

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