| Prevalence and risk factors for pulmonary arterial hypertension in patients with lupus. | |
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MedLine Citation:
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PMID: 19671698 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVES: Pulmonary arterial hypertension (PAH) is associated with rapid deterioration and poor prognosis in SLE, especially during pregnancy. The prevalence of PAH in SLE in non-tertiary centres is uncertain. This study aims to estimate the point prevalence of PAH and identify risk factors for PAH in a large cohort of SLE patients. METHODS: A prospective cross-sectional study of 288 patients with SLE were recruited from lupus clinics in Birmingham, UK. Resting transthoracic echocardiography was performed to estimate the pulmonary artery pressures and to assess cardiac morphology and function. PAH was defined as systolic pulmonary artery pressure (sPAP) >30 mmHg. We assessed potential risk factors such as the presence of lung disease, respiratory muscle weakness, autoantibodies, smoking, RP and APS. RESULTS: Of 288 patients who consented for participation, 283 patients were suitable for analysis. Twelve patients were found to have PAH with sPAP >30 mmHg. The range of sPAP in our PAH patients was 31-59 mmHg and three patients had sPAP >40 mmHg. The only significant risk factor for PAH was LAC (P = 0.005). CONCLUSIONS: The point prevalence of PAH was 4.2% in our cohort of patients with SLE. Most of the PAH cases were found to be of mild severity (<40 mmHg). The significant association of LAC and presence of APS in PAH cases suggests that thrombosis may play an important role in PAH with SLE. This is important, as it is treatable. |
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Authors:
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Athiveeraramapandian Prabu; Kiran Patel; Chee-Seng Yee; Peter Nightingale; Rohan D Situnayake; David R Thickett; Jonathan N Townend; Caroline Gordon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-11 |
Journal Detail:
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Title: Rheumatology (Oxford, England) Volume: 48 ISSN: 1462-0332 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: England |
Other Details:
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Languages: eng Pagination: 1506-11 Citation Subset: AIM; IM |
Affiliation:
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Department of Rheumatology, Division of Infection and Immunology, University of Birmingham, Birmingham, UK. |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Comments/Corrections | |
Comment In:
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Rheumatology (Oxford). 2009 Dec;48(12):1471-2
[PMID:
19710237
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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