| Prevalence of and risk factors for pre-diabetes in HIV-1-infected patients in Bangkok, Thailand. | |
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MedLine Citation:
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PMID: 21075913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pre-diabetes substantially increases the risk of developing macrovascular complication and progression to diabetes. This study aimed to determine the prevalence of and risk factors for pre-diabetes in HIV-1-infected patients. A cross-sectional study was conducted in HIV-1-infected patients who visited the infectious diseases clinic in a university hospital. Fasting plasma glucose (FPG) was performed. There were 149 patients, mean age 42.2 years, and 65.1% were males. Median CD4 count was 434 cells/mm(3). In total, 92% have received antiretroviral therapy (ART), with a median duration of 0.8 years. The prevalence of pre-diabetes was 27.5%. From multivariate analysis, body weight ([BW] per 5 kg increase, odds ratio [OR] = 1.241; 95% confidence interval [CI], 1.014-1.518; P = .036) and, tentatively, male gender (OR = 2.906; 95% CI, 0.941-8.976; P = .064) were risk factors for pre-diabetes. Nevirapine (NVP) use (OR = 0.383; 95% CI, 0.161-0.910; P = .030) was a protective factor for pre-diabetes. Pre-diabetes is common in HIV-1-infected patients receiving ART. Screening for pre-diabetes and active management should be performed in patients with risk factors. |
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Authors:
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Nopporn Srivanich; Chardpraorn Ngarmukos; Somnuek Sungkanuparph |
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Publication Detail:
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Type: Journal Article Date: 2010-11-12 |
Journal Detail:
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Title: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Volume: 9 ISSN: 1545-1097 ISO Abbreviation: J Int Assoc Physicians AIDS Care (Chic) Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-12-08 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101185740 Medline TA: J Int Assoc Physicians AIDS Care (Chic) Country: United States |
Other Details:
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Languages: eng Pagination: 358-61 Citation Subset: IM |
Affiliation:
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Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-HIV Agents / adverse effects, pharmacology* Cross-Sectional Studies Female HIV Infections / drug therapy*, epidemiology* HIV-1* Humans Logistic Models Male Multivariate Analysis Nevirapine / adverse effects, pharmacology* Prediabetic State / chemically induced, epidemiology* Prevalence Risk Factors Thailand / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 129618-40-2/Nevirapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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