Document Detail


Prevalence, risk factors and mortality of pulmonary hypertension defined by right heart catheterization in patients with sickle cell disease.
MedLine Citation:
PMID:  22077523     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Evaluation of: Parent F, Bachir D, Inamo J et al. A hemodynamic study of pulmonary hypertension in sickle cell disease. N. Engl. J. Med. 365(1), 44?53 (2011); Fonseca GH, Souza R, Salemi VM, Jardim CV, Gualandro SF. Pulmonary hypertension diagnosed by right heart catheterization in sickle cell disease. Eur. Respir. J. doi:10.1183/09031936.00134410 (2011) (Epub ahead of print). Three new large screening studies of patients with sickle cell disease for pulmonary hypertension have now been published. Two of these studies included comprehensive right heart catheterization of all patients with an elevation in the estimated pulmonary artery systolic pressure. Together, these studies show that pulmonary hypertension, defined by a mean pulmonary artery pressure greater than or equal to 25 mmHg, occurs in approximately 10% of all adult sickle cell disease patients. Pulmonary hypertension in these studies is associated with hemolytic anemia, renal insufficiency, leg ulcers, increasing age, low exercise capacity and high levels of N-terminal pro-brain natriuretic peptide, but not with the rates of vaso-occlusive crisis or the acute chest syndrome, confirming prior epidemiological studies in adult sickle cell disease patients. The presence of pulmonary hypertension diagnosed by echocardiography or right heart catheterization indicates a significant and independent risk factor for prospective mortality.
Authors:
Mark T Gladwin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of hematology     Volume:  4     ISSN:  1747-4094     ISO Abbreviation:  Expert Rev Hematol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485942     Medline TA:  Expert Rev Hematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  593-6     Citation Subset:  IM    
Affiliation:
Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA. gladwinmt@upmc.edu.
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