| Prevalence and risk factors associated with development of ocular GVHD defined by NIH consensus criteria. | |
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MedLine Citation:
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PMID: 22484321 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We studied 172 patients for development of ocular graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) from 2002 to 2009. Ocular GVHD was diagnosed in 60 patients (38%), with 27 (16%) being diagnosed at days 100 and 33 (23%) beyond day 100 for a 2-year cumulative incidence of 35% (95% confidence interval (CI), 28-43). The positive and negative predictive values of a Schirmer I test score (using 5 mm as a cutoff) in predicting ocular GVHD (day 100) were 41 and 82%, respectively. In patients with ocular GVHD beyond day 100, extraocular manifestations of GVHD preceded the development of ocular GVHD in most patients (27 of 33, 81%). Prior acute skin GVHD (odds ratio 2.57, 95% CI 1.17-5.64, P=0.019) and male recipients of female donors (odds ratio 2.57, 95% CI 1.09-6.06, P=0.03) were independent risk factors for ocular GVHD. We recommend comprehensive ocular evaluation rather than a screening Schirmer's test to establish the diagnosis of ocular GVHD. Early diagnosis and preventive strategies in high-risk populations need to be studied in clinical trials to prevent devastating impact on quality of life in patients with prolonged ocular GVHD.Bone Marrow Transplantation advance online publication, 9 April 2012; doi:10.1038/bmt.2012.56. |
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Authors:
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R Jacobs; U Tran; H Chen; A Kassim; B G Engelhardt; J P Greer; S G Goodman; C Clifton; C Lucid; L A Vaughan; B N Savani; M Jagasia |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-09 |
Journal Detail:
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Title: Bone marrow transplantation Volume: - ISSN: 1476-5365 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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