Document Detail

Prevalence of pulmonary hypertension in patients with schistosomal liver fibrosis.
MedLine Citation:
PMID:  19208297     Owner:  NLM     Status:  MEDLINE    
Between the April and July of 2007, patients undergoing treatment for schistosomal liver fibrosis, at a university hospital in north-eastern Brazil, were examined by transthoracic Doppler echocardiography (TTE). The main aim was to determine the prevalence of pulmonary hypertension in the patients. The thorax of each patient who had such hypertension, as indicated by an estimated pulmonary arterial systolic pressure (PASP) in excess of 35 mmHg, was then investigated by contrast-enhanced multidetector-row computed tomography (MDCT). The 84 patients (53 women and 31 men) enrolled in the study had a mean (S.D.) age of 50.06 (12.25) years. Nine (10.7%, with a 95% confidence interval of 5.0%-19.4%) of the patients were found to have pulmonary hypertension, with PASP ranging from 40-126 mmHg, and a median (S.D.) PASP of 58.78 (28.01) mmHg. The contrast-enhanced thoracic MDCT indicated that most of the patients with pulmonary hypertension had a pulmonary artery trunk that was unusually wide (67%) and more than 1.1-fold wider than the ascending aorta (56%), dilatation of the main pulmonary arteries (100%), a segmental artery that, in diameter, was more than 1.1-fold larger than the adjacent bronchi (89%), tapering of the peripheral pulmonary arteries (78%), and cardiac enlargement (78%). No patient suffered pulmonary embolism as a result of the investigations. The prevalence of pulmonary hypertension in the patients with schistosomal liver fibrosis (10.7%) justifies the screening of such patients by TTE.
R C S Ferreira; A L C Domingues; A P Bandeira; B Markman Filho; E S Albuqerque Filho; A C C Correiade de Ara??jo; L J B Batista; M Markman; A R L Campelo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of tropical medicine and parasitology     Volume:  103     ISSN:  0003-4983     ISO Abbreviation:  Ann Trop Med Parasitol     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-11     Completed Date:  2010-02-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985178R     Medline TA:  Ann Trop Med Parasitol     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-43     Citation Subset:  IM    
University Hospital Oswaldo Cruz (HUOC), University of Pernambuco, Rua Arn??bio Marques, 310, Santo Amaro, CEP 50100-130, Recife, PE, Brazil.
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MeSH Terms
Echocardiography, Doppler
Forced Expiratory Volume
Hypertension, Pulmonary / parasitology*,  physiopathology,  radiography,  ultrasonography
Liver Cirrhosis / parasitology*,  physiopathology
Liver Diseases, Parasitic / complications*,  physiopathology,  ultrasonography
Middle Aged
Pulmonary Artery / pathology,  radiography
Schistosomiasis mansoni / complications*,  physiopathology,  ultrasonography
Smoking / adverse effects
Tomography, X-Ray Computed
Vital Capacity
Young Adult

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