Document Detail

Prevalence of pulmonary disorders in patients with newly diagnosed rheumatoid arthritis.
MedLine Citation:
PMID:  10870658     Owner:  NLM     Status:  MEDLINE    
Our objective was to determine the prevalence of airway hyperreactivity (AHR) in patients with newly diagnosed rheumatoid arthritis (RA) who had received no disease-modifying antirheumatic drugs (DMARDs) and to characterise the spectrum of lung diseases identifiable in these patients at the time of presentation. Eighteen consecutive patients with newly diagnosed RA referred to our medical centre's rheumatology clinic over 2 years underwent pulmonary evaluation with arterial blood gas analysis, chest radiographs, spirometry before and after bronchodilator medication, and body plethysmography. They returned on subsequent days in random order for methacholine inhalation challenge (MIC) and eucapnic voluntary hyperventilation (EVH) as bronchoprovocation techniques. One patient had severe obstructive disease at presentation and therefore did not undergo bronchoprovocation. We found a wide variety of pulmonary abnormalities, including two patients with hypoxia (12%), two with obstruction (12%), three with restriction (18%) and four with AHR (23%). The data also suggest a strong association between pulmonary diseases in RA and cigarette smoking. Although no single characteristic lung disease such as AHR was identified in patients presenting with RA, the association between lung disease and cigarette smoking is striking and underscores the need to emphasise smoking cessation in this patient population.
J J Doyle; A H Eliasson; G J Argyros; G J Dennis; D R Finger; K M Hurwitz; Y Y Phillips
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical rheumatology     Volume:  19     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2000  
Date Detail:
Created Date:  2000-09-25     Completed Date:  2000-11-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  217-21     Citation Subset:  IM    
Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA.
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MeSH Terms
Arthritis, Rheumatoid / complications*
Bronchial Hyperreactivity / complications*,  diagnosis,  epidemiology*,  etiology
Bronchial Provocation Tests / methods
Bronchoconstrictor Agents / diagnostic use
Forced Expiratory Volume
Methacholine Chloride / diagnostic use
Middle Aged
Smoking / adverse effects
Total Lung Capacity
Reg. No./Substance:
0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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