Document Detail

Prevalence, prognostic importance and therapeutic implications of anemia in heart failure.
MedLine Citation:
PMID:  16521636     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Despite advances in its management, heart failure, once established, remains highly prevalent and lethal. Anemia can exacerbate the hemodynamic burden in heart failure. The present study was undertaken to assess the presence of anemia and analyze how its control impacts the outcome in heart failure patients. METHODS AND RESULTS: From a cohort of 238 heart failure patients, 55 (231%) patients were found to be anemic. Twenty-nine patients (Group A) were given recombinant human erythropoietin for 12 weeks along with iron, and followed up for a mean period of 24 +/- 6 months. The patients improved substantially in terms of functional capacity (6 min walk test improved from 232 +/- 35 m to 278 +/- 41 m, p < 0.001), hemoglobin level from 10.1 +/- 0.90 gm/dl to 12 +/- 0.7 gm/dl, (p < or = 0.001), and ejection fraction from 33 +/- 7.1% to 41 +/- 6.9% (p < or = 0.001). Twenty-six patients (Group B) who were age- and sex-matched with Group A and had similar degree of functional disability and left ventricular dysfunction as that of Group A were not given erythropoietin and iron. Thus, Group B patients served as controls. In comparison to Group B, Group A patients demonstrated not only higher hemoglobin level (12 +/- 0.7 gm/dl v. 9.8 +/- 0.9 gm/dl, p < or = 0.001), and ejection fraction (41 +/- 6.9% v. 26 +/- 7%, p < or = 0.05), but also better survival (16/29 v. 7/26, p < 0.05, odds ratio 1.27). CONCLUSIONS: Anemia is a significant predictor of poor outcome in patients with heart failure. Administration of erythropoietin can correct anemia and help improve survival.
Trinath K Mishra; Sura K Mishra; Nirmal K Mohanty; Pravin K Rath
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Indian heart journal     Volume:  57     ISSN:  0019-4832     ISO Abbreviation:  Indian Heart J     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2006-03-08     Completed Date:  2006-04-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374675     Medline TA:  Indian Heart J     Country:  India    
Other Details:
Languages:  eng     Pagination:  670-4     Citation Subset:  IM    
Department of Cardiology, MKCG Medical College and Hospital, Berhampur.
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MeSH Terms
Age Distribution
Anemia, Iron-Deficiency / diagnosis,  drug therapy*,  epidemiology*
Case-Control Studies
Erythropoietin, Recombinant / therapeutic use*
Heart Failure / diagnosis,  drug therapy,  epidemiology*
Middle Aged
Odds Ratio
Predictive Value of Tests
Risk Assessment
Severity of Illness Index
Sex Distribution
Survival Analysis
Treatment Outcome
Reg. No./Substance:
0/Erythropoietin, Recombinant

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