| Prevalence and prognostic implications of non-sustained ventricular tachycardia in ST-segment elevation myocardial infarction after revascularization with either fibrinolysis or primary angioplasty. | |
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MedLine Citation:
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PMID: 17227787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: We compared the prevalence and prognostic implications of non-sustained ventricular tachycardia (nsVT) detected early after ST-segment elevation myocardial infarction (STEMI) in patients randomized to either fibrinolysis or primary angioplasty in the DANAMI-2 trial. METHODS AND RESULTS: Holter recordings were available in 1017 patients (fibrinolysis: n=501; primary angioplasty: n=516). Primary endpoint was all-cause mortality. The prevalence of nsVT was 8.8% in fibrinolysis-treated, and 8.1% in primary angioplasty-treated patients (P=0.71). During 4519 patient-years of follow-up (median 4.3 years), 116 patients died [fibrinolysis vs. angioplasty: HR=1.1 (95% CI, 0.8-1.6), P=0.47]. In univariate analysis, nsVT patients treated with fibrinolysis, had significantly higher mortality when compared with those without nsVT (P<0.001). However, after adjustment for other relevant prespecified risk factors, the association between nsVT and mortality did not remain statistically significant. In patients treated with primary angioplasty, nsVT was not associated with mortality in either univariate or multivariate analyses. CONCLUSION: Immediate revascularization with primary angioplasty for STEMI does not affect the subsequent prevalence of nsVT when compared with fibrinolysis. After adjustment for other relevant risk factors, the prognostic value of nsVT detected early after STEMI is limited, regardless of the chosen reperfusion strategy. |
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Authors:
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Dan Eik Høfsten; Kristian Wachtell; Birgit Lund; Henning Mølgaard; Kenneth Egstrup |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-01-16 |
Journal Detail:
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Title: European heart journal Volume: 28 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-16 Completed Date: 2007-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 407-14 Citation Subset: IM |
Affiliation:
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Department of Medical Research, Svendborg Hospital, 5700 Svendborg, and Department of Cardiology, Skejby Sygehus, Arhus University Hospital, Denmark. dan@hoefsten.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Analysis of Variance Angioplasty / mortality* Electrocardiography, Ambulatory Female Humans Male Middle Aged Myocardial Infarction / mortality, physiopathology, therapy* Myocardial Revascularization / methods*, mortality Prognosis Survival Analysis Tachycardia, Ventricular / mortality, physiopathology, therapy* Thrombolytic Therapy / mortality* Ventricular Dysfunction, Left / etiology, mortality, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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