Document Detail


Prevalence of primary sclerosing cholangitis in patients with ulcerative colitis.
MedLine Citation:
PMID:  2013375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
All patients greater than or equal to 16 years old with a diagnosis of ulcerative colitis were identified in five well-defined catchment areas, representing 12.7% of the Swedish population. Exactly 1500 patients were retrieved, giving a point prevalence of 170/10(5) inhabitants. It was possible to obtain liver function test results less than 2 years old in 94% of the patients and to obtain endoscopic retrograde cholangiographic results in 65 of the 72 patients with abnormal serum alkaline phosphatase values. Primary sclerosing cholangitis was diagnosed in 55 of the patients (3.7%). The prevalence of the disease was 5.5% in patients with substantial colitis and 0.5% in patients with distal colitis. There was a marked male predominance in cholangitis patients compared with colitis patients without cholangitis. Ninety-five percent of the patients with cholangitis had substantial colitis, which was more than the 62% of patients without cholangitis who had colitis. Female patients with cholangitis were older than male patients at the time of diagnosis of both cholangitis and colitis, which contrasted to the equal age at diagnosis of colitis in male and female patients without cholangitis.
Authors:
R Olsson; A Danielsson; G Järnerot; E Lindström; L Lööf; P Rolny; B O Rydén; C Tysk; S Wallerstedt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  100     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-05-13     Completed Date:  1991-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1319-23     Citation Subset:  AIM; IM    
Affiliation:
Medical Clinics at Sahlgrenska Sjukhuset, Göteborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alanine Transaminase / blood
Alkaline Phosphatase / blood
Aspartate Aminotransferases / blood
Cholangiopancreatography, Endoscopic Retrograde
Cholangitis, Sclerosing / epidemiology*,  etiology
Colitis, Ulcerative / complications*,  epidemiology
Female
Humans
Male
Middle Aged
Prevalence
Sweden / epidemiology
Chemical
Reg. No./Substance:
EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase

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