Document Detail


Prevalence and predictors of upper airway obstruction in the first 24 hours after acute stroke.
MedLine Citation:
PMID:  12154259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: The prevalence of sleep-disordered breathing after stroke has been reported to be between 32% and 71%. However, the first 24-hour period, when upper airway obstruction may have a critical effect on the cerebral circulation because of hemodynamic fluctuations and repetitive hypoxia, has not been studied. Furthermore, data on prediction of upper airway obstruction after stroke are limited. This study sought to assess the prevalence of upper airway obstruction in the first 24 hours of stroke and to ascertain whether its occurrence could be predicted. METHODS: One hundred twenty patients with acute stroke underwent a respiratory variable-only sleep study, started within 24 hours of onset of neurological symptoms. Sleep history and stroke characteristics were recorded on admission. RESULTS: We found that 79%, 61%, and 45% of the patients had a respiratory disturbance index greater than 5, 10, and 15 events per hour, respectively. Patients had a significantly higher respiratory disturbance index when nursed in the supine (29 events per hour), supine left (29 events per hour), and supine right (24 events per hour) positions than in any other position (P<0.0001). On logistic regression analysis, BMI (P=0.025), neck circumference (P=0.026), and limb weakness (P=0.025) independently predicted the occurrence of upper airway obstruction in the first 24 hours after acute stroke. CONCLUSIONS: Upper airway obstruction is common in the first 24 hours after stroke, especially if patients are nursed in the supine position, and typical obstructive sleep apnea risk factors (body mass index and neck circumference) appear to be the best predictors of its occurrence. Stroke characteristics (severity, clinical subtype, and clinically assessed pharyngeal function) are not independently associated with upper airway obstruction after stroke.
Authors:
P M Turkington; J Bamford; P Wanklyn; M W Elliott
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  33     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-02     Completed Date:  2002-08-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2037-42     Citation Subset:  IM    
Affiliation:
Department of Respiratory Medicine, The Leeds Teaching Hospitals National Health Service Trust, Leeds, UK.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Airway Obstruction / diagnosis*,  epidemiology,  physiopathology
Causality
Comorbidity
Female
Humans
Logistic Models
Male
Polysomnography
Predictive Value of Tests
Prevalence
Pulmonary Ventilation
Risk Factors
Severity of Illness Index
Sleep Apnea, Obstructive / diagnosis*,  epidemiology
Stroke / classification,  diagnosis,  epidemiology*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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