Document Detail


Prevalence, predictors, and prognostic impact of fatigue among Brazilian outpatients with advanced cancers.
MedLine Citation:
PMID:  23052924     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSES: The purposes of this study are to evaluate the impact of cancer-related fatigue (CRF) on quality of life (QoL), and to identify its clinical predictors. In addition, the authors investigated the prognostic impact of CRF and its relationship with the inflammatory marker C-reactive protein. METHOD: Data regarding patient characteristics, symptom scores, and QoL indices were collected at the initial evaluation. At the same time, blood samples were collected in order to evaluate some laboratorial markers. Patients were followed by telephone interviews every 15 days until death. CRF was defined as ≥66.67 points on EORTC QLQ-C30 fatigue subscale. RESULTS: The examined patients had a median age of 61 years (range, 21-86 years) and 50.7 % were male. Median Karnofsky performance score (KPS) was 75.5 (SD, 15.1). The prevalence of CRF was 25 % (55 out of 221). Overall, patients with CRF presented higher symptom burden and also worst QoL scores. The following variables were independently associated with CRF: nausea (OR 1.22, p = 0.009), dyspnea (OR 1.33, p = 0.002), KPS (OR 0.96, p = 0.009), body mass index (OR 0.93, p = 0.046), and C-reactive protein (OR 1.08, p = 0.004). The median overall survival (OS) was lower in CRF patients (p < 0.0001). Only KPS (HR = 0.96, p < 0.001) and C-reactive protein (HR = 1.07, p < 0.001) were independent prognostic factors for OS. CONCLUSIONS: Advanced cancer patients (ACP) with CRF had a higher burden of symptoms and impaired QoL. Our findings support the hypothesis that chronic inflammatory state (CIS) could play a role in the pathogenesis of fatigue in ACP. Moreover, CIS seems to have greater prognostic impact than the associated fatigue.
Authors:
Carlos Eduardo Paiva; Bianca Sakamoto Ribeiro Paiva
Related Documents :
24705344 - Clinicopathologic characterization of diffuse-large-b-cell lymphoma with an associated ...
8756384 - Is there a correlation between duration of presenting symptoms and stage of medulloblas...
23065574 - Ilk and prdx1 are prognostic markers in squamous cell/adenosquamous carcinomas and aden...
18712684 - Results after intensified therapy for advanced carcinoma of the hypopharynx.
23291254 - Radiotherapy alone vs. radiochemotherapy in patients with favorable prognosis of clinic...
23218594 - Chemoradiation in anaplastic thyroid carcinomas.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer     Volume:  -     ISSN:  1433-7339     ISO Abbreviation:  Support Care Cancer     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9302957     Medline TA:  Support Care Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Clinical Oncology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil, caredupai@gmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Low body mass index as a risk factor of moderate to severe oral mucositis in oral cancer patients wi...
Next Document:  Altered Host Cell-Bacteria Interaction due to Nanoparticle Interaction with a Bacterial Biofilm.