Document Detail

Prevalence and predictors of low vitamin D status in patients referred to a tertiary photodiagnostic service: a retrospective study.
MedLine Citation:
PMID:  22409712     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND/PURPOSE: Low vitamin D levels have been associated with adverse effects on health. The primary source of vitamin D is cutaneous production during sunlight exposure. Sun avoidance can restrict vitamin D photosynthesis and is common practice amongst patients with photosensitivity. Few studies have examined vitamin D status in this population, particularly those in northern latitudes. The purpose of this study was therefore to investigate the prevalence and possible predictors of low vitamin D status in patients referred to a tertiary photodiagnostic service.
METHODS: A case note review of 165 patients who attended the National Photodiagnostic Service for assessment at the Photobiology Unit in Dundee, Scotland (latitude 56°N) over 1 year was conducted. Clinical information and serum 25-hydroxyvitamin D (25(OH)D) concentration were documented. Multivariate analyses were used to identify predictors of vitamin D status.
RESULTS: Mean 25(OH)D concentration was 41.9 nmol/L [standard deviation (SD) 22.0]. Forty percent of patients had insufficient vitamin D levels [25(OH)D 25-49 nmol/L] and 25% were vitamin D deficient [25(OH)D < 25 nmol/L]. Blood collection in winter was the strongest predictor of low 25(OH)D status (P < 0.001); strict photoprotection (P = 0.04), onset of symptoms within an hour of sunlight exposure (P = 0.01) and abnormal monochromator phototesting responses (P = 0.009) also predicted low vitamin D levels. Supplement use was associated with higher vitamin D levels (P < 0.001), even amongst patients who strictly avoided sunlight (P = 0.03).
CONCLUSIONS: Patients with photosensitivity who live in northern latitudes are at high risk of low vitamin D levels, particularly in winter and spring. Increased awareness of this risk is crucial to ensure preventative strategies, such as supplementation, are implemented.
Suzanne M Reid; Mark Robinson; Alastair C Kerr; Sally Helen Ibbotson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Photodermatology, photoimmunology & photomedicine     Volume:  28     ISSN:  1600-0781     ISO Abbreviation:  Photodermatol Photoimmunol Photomed     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013641     Medline TA:  Photodermatol Photoimmunol Photomed     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  91-6     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Photobiology Unit, Ninewells Hospital & Medical School, Dundee, UK.
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