| Prevalence of, and predictors of, bile acid malabsorption in outpatients with chronic diarrhea. | |
| | |
MedLine Citation:
|
PMID: 22765392 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background Many physicians do not consider the diagnosis of bile acid malabsorption in patients with chronic diarrhea, or do not have access to testing. We examined yield of 23-seleno-25-homo-tauro-cholic acid (SeHCAT) scanning in chronic diarrhea patients, and attempted to identify predictors of a positive test. Methods Consecutive patients with chronic diarrhea undergoing SeHCAT scan over a 7-year period were identified retrospectively. Bile acid malabsorption was defined as present at a retention of <15%. Medical records were reviewed to obtain information regarding proposed risk factors. Gastrointestinal symptoms were recorded, and patients were classified as having diarrhea-predominant irritable bowel syndrome (IBS-D) if they reported abdominal pain or discomfort. Independent risk factors were assessed using multivariate logistic regression, and odds ratios (ORs) with 99% confidence intervals (CIs) were calculated. Key Results Of 373 patients, 190 (50.9%) had bile acid malabsorption. Previous cholecystectomy (OR 2.51; 99% CI 1.10-5.77), terminal ileal resection or right hemicolectomy for Crohn's disease (OR 12.4; 99% CI 2.42-63.8), and terminal ileal resection or right hemicolectomy for other reasons (OR 7.94; 99% CI 1.02-61.6) were associated with its presence. Seventy-seven patients had IBS-D, and 21 (27.3%) tested positive. There were 168 patients with no risk factors for a positive SeHCAT scan, other than chronic diarrhea, and 63 (37.5%) had bile acid malabsorption. Conclusions & Inferences Bile acid malabsorption was present in 50% of patients undergoing SeHCAT scanning. Almost 40% of those without risk factors had evidence of bile acid malabsorption, and in those meeting criteria for IBS-D prevalence was almost 30%. |
| | |
Authors:
|
D J Gracie; J S Kane; S Mumtaz; A F Scarsbrook; F U Chowdhury; A C Ford |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-5 |
Journal Detail:
|
Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: - ISSN: 1365-2982 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 Blackwell Publishing Ltd. |
Affiliation:
|
Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK Department of Nuclear Medicine, St. James's University Hospital, Leeds, UK Leeds Institute of Molecular Medicine, Leeds University, Leeds, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Topological features of cancer proteins in the human NR-RTK interaction network.
Next Document: The meaning of the lived experiences of adults with intellectual disabilities in a Swedish instituti...