Document Detail


Prevalence of positive ppd in a cohort of rheumatoid arthritis patients.
MedLine Citation:
PMID:  19578852     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The main objective of this study is to determine the prevalence of positive and anergic tuberculin skin test (ppd) in a rheumatoid arthritis cohort of patients (RA) and assess the association among ppd results and clinical and treatment variables. Patients with RA diagnosis were included. The ppd was done by Mantoux method. Positive result was considered when indurations were equal or greater than 5 mm. Anergic reaction was defined when the indurations was 0 mm. We included 105 patients (N = 105). The prevalence of positive ppd was 12.4% (n = 13), while the 87.6% (n = 92) presented a negative result. The 69.5% (n = 73) of the population were anergic to ppd. Patients with negative result received higher steroids dosages than patients with positive ppd (p < 0.04). In the multivariable model, the steroids dosage was a significant and independent predictor of negative ppd (p = 0.021, OR 0.72, 95% CI 0.55-0.95). Anergic and non-anergic patients were separated in groups, and a new analysis was done. The higher dosage of methotrexate was associated to tuberculine anergy (p = 0.025). In the multivariable model, the methotrexate dosage was a significant and independent predictor of tuberculine anergy (p = 0.005, OR 1.14, 95% CIs 1.04-1.24). In conclusion, in our cohort, the prevalence of positive ppd was lower than others studies. Among analyzed variables, the high steroid dose was a significant and independent predictor of negative ppd. The methotrexate treatment and dose were associated with ppd anergy.
Authors:
Maria Natalia Tamborenea; Guillermo Tate; Eduardo Mysler; Jose Debonis; Adrian Schijedman
Publication Detail:
Type:  Journal Article     Date:  2009-07-04
Journal Detail:
Title:  Rheumatology international     Volume:  30     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  613-6     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, Organizaci?n M?dica de Investigaci?n, Uruguay, 725 PB, C1015ABO, Ciudad Aut?noma de Buenos Aires, Argentina. nataliatamborenea@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antirheumatic Agents / administration & dosage*
Argentina
Arthritis, Rheumatoid / complications,  diagnosis,  drug therapy*,  immunology
Biological Products / administration & dosage
Cross-Sectional Studies
Female
Humans
Isoxazoles / administration & dosage
Latent Tuberculosis / complications,  diagnosis*,  immunology
Logistic Models
Male
Methotrexate / administration & dosage
Middle Aged
Predictive Value of Tests
Risk Assessment
Risk Factors
Steroids / administration & dosage
Treatment Outcome
Tuberculin Test*
Tumor Necrosis Factor-alpha / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Antirheumatic Agents; 0/Biological Products; 0/Isoxazoles; 0/Steroids; 0/Tumor Necrosis Factor-alpha; 59-05-2/Methotrexate; 75706-12-6/leflunomide

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