Document Detail

Prevalence of patent foramen ovale and usefulness of percutaneous closure device in carcinoid heart disease.
MedLine Citation:
PMID:  18359327     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to assess (1) the incidence of patent foramen ovale (PFO) in carcinoid syndrome (CS) and (2) the feasibility of percutaneous closure procedure in selected patients with CS. One hundred eight patients were prospectively studied: 54 with CS and an age- and gender-matched control group. All patients underwent conventional and contrast echocardiography. Patients with clinical signs of dyspnea (New York Heart Association class > or =III), cyanosis, carcinoid heart disease (CHD), and severe PFO were referred for the percutaneous closure of PFO. The prevalence of PFO was 41% in patients with CS and 22% in the control group (p = 0.03) and was significantly higher in patients with CHD (59%, p = 0.009). Four patients (14% of those with CHD) were referred for the percutaneous closure of PFO, and 3 patients ultimately underwent PFO closure (using Amplatzer septal occluders). At 6-month follow-up, New York Heart Association class was improved in all patients, as well as arterial blood gas results (p = 0.04) and 6-minute walking distance (p = 0.03), but all patients presented residual right-to-left shunts. In conclusion, this prospective study demonstrates that in patients with CHD, the prevalence of PFO is high and that percutaneous closure of PFO is feasible, with a reduction in symptoms but with residual shunting.
Nicolas Mansencal; Emmanuel Mitry; Rémy Pillière; Céline Lepère; Benoît Gérardin; Jérôme Petit; Iradj Gandjbakhch; Philippe Rougier; Olivier Dubourg
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-02-11
Journal Detail:
Title:  The American journal of cardiology     Volume:  101     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-24     Completed Date:  2008-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1035-8     Citation Subset:  AIM; IM    
Department of Cardiology, Université de Versailles-Saint Quentin, University Hospital Ambroise Paré, Assistance Publique-Hôpitaux de Paris, Boulogne, France. <>
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MeSH Terms
Carcinoid Heart Disease / complications,  epidemiology*
Case-Control Studies
Feasibility Studies
Foramen Ovale, Patent / complications,  epidemiology*,  therapy*
Heart Catheterization
Middle Aged
Prospective Studies
Prosthesis Implantation*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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