Document Detail


Prevalence and particularities of dyslipidaemia in subjects with coronary heart disease.
MedLine Citation:
PMID:  18767409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the study was to evaluate the lipid profile and the prevalence of dyslipidaemia and other risk factors in subjects with and without coronary heart disease. METHODS: We conducted a retrospective study in 1519 subjects, admitted in Internal Medicine and Cardiology Department, Cluj-Napoca between January 2003 and December 2004. The first group consisted of 760 patients with coronary heart disease and the second group including 759 subjects in which coronary heart disease was excluded based on standard criteria. The cardiovascular risk factors and the serum lipid fractions were analyzed in order to test their relationship with the demographic characteristics and clinical forms of coronary heart disease. RESULTS: The mean values of lipid fractions were lower in subjects with coronary heart disease than in subjects without coronary heart disease: total cholesterol (204.44 +/- 43.07 vs. 224.51 +/- 51.73 mg/dl, p = 0.0001), LDL-cholesterol (132.69 +/- 34.77 vs. 148.76 +/- 48.72 mg/dl, p = 0.0001), HDL-cholesterol (39.72 +/- 10.02 vs. 44.33 +/- 11.95 mg/dl, p = 0.0001), triglycerides (156.81 +/- 70.84 vs. 159.99 +/- 115.3 mg/dl, p = 0.517), non-HDL-cholesterol (164.72 +/- 39.9 vs. 180.19 +/- 51.58 mg/dl, p = 0.0001). The prevalence of dyslipidaemia was higher in group 1 than in group 2 (91.2% vs. 85.3%; p = 0.01). The most common lipid abnormalities in patients with coronary heat disease were increased LDL-C (84.22% vs. 81.21%, p = 0.09), followed by low HDL-C (55.26% vs. 35.57%, p = 0.001). The multivariate analysis showed that LDL-C (OR 1.27; 95% CI 1.01-1.88, p = 0.004), TC/HDL-C > 4.5 (OR 3.62; 95% CI 2.85-8.86, p = 0.001) and LDL-C/HDL-C > 3.5 (OR 4.21; 95% CI 1.89-4.66, p = 0.001) ratio, as being strongly associated with coronary events. CONCLUSION: The study found a high prevalence of dyslipidaemia in Romanian patients with coronary heart disease. The most frequent lipid disorders were increased LDL-C, and low HDL-C. According to our results more than 90% of the patients with coronary heart disease are dyslipidaemic, and require non-pharmacological or pharmacological therapy.
Authors:
Lucica Agoşton-Coldea; D Zdrenghea; Dana Pop; Alexandra Crăciun; M L Rusu; Teodora Mocan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Romanian journal of internal medicine = Revue roumaine de médecine interne     Volume:  45     ISSN:  1220-4749     ISO Abbreviation:  Rom J Intern Med     Publication Date:  2007  
Date Detail:
Created Date:  2008-09-04     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304507     Medline TA:  Rom J Intern Med     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  341-7     Citation Subset:  IM    
Affiliation:
"Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. lucicoldea@yahoo.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Case-Control Studies
Coronary Disease / blood,  complications*
Dyslipidemias / complications*,  epidemiology
Female
Humans
Lipoproteins / blood
Male
Middle Aged
Prevalence
Retrospective Studies
Romania / epidemiology
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Lipoproteins; 0/Triglycerides

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