Document Detail

Prevalence of the partial molar phenotype in triploidy of maternal and paternal origin.
MedLine Citation:
PMID:  9596275     Owner:  NLM     Status:  MEDLINE    
Triploid partial moles are at risk for trophoblastic neoplasia, yet the prevalence, parent of origin, and evolution of the partial molar phenotype amongst all triploids remains controversial. We determined parental origin by polymerase chain reaction (PCR) analysis, stage of development by gross and histological criteria, and partial molar status according to strict diagnostic criteria for all triploids identified amongst 1,054 consecutively karyotyped spontaneous abortions. Triploidy was detected in 64 of 832 successfully karyotyped specimens. Complete data were collected in 59 cases. Diandric origin was found in 39 specimens, and 20 of these fulfilled all four criteria for partial mole (trophoblast hyperplasia, dimorphic population of large and small villi, villous hydrops greater than 0.5 mm, and irregular villous contour). We separated the 19 diandric triploids not fulfilling all criteria for partial mole into four groups: specimens of early developmental stage, which we believed represented developing ("early") partial moles (n = 3), cases of late developmental stage, which we believed represented involuting ("ancient") partial moles (n = 4), cases showing some but not all criteria for partial mole (n = 7), and specimens with few if any criteria suggestive of partial mole (n = 5). In triploids of digynic origin (n = 20), developmental stage was significantly lower, fetal tissue was more frequently identified, and all specimens showed well-preserved fetal red blood cells. Digynic triploids occasionally showed irregular contour, dimorphic villi, and a mild form of trophoblast hyperplasia but never showed hydropic degeneration and were never suspicious for partial mole.
R W Redline; T Hassold; M V Zaragoza
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human pathology     Volume:  29     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-04     Completed Date:  1998-06-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  505-11     Citation Subset:  IM    
Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, OH 44106, USA.
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MeSH Terms
DNA, Neoplasm / analysis
Hydatidiform Mole / genetics,  pathology*
Polymerase Chain Reaction
Trophoblastic Neoplasms / genetics,  pathology*
Uterine Neoplasms / genetics,  pathology*
Grant Support
Reg. No./Substance:
0/DNA, Neoplasm

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