Document Detail

Prevalence of paroxysmal atrial fibrillation in Brugada syndrome: a case series and a review of the literature.
MedLine Citation:
PMID:  17885518     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The present study aimed at investigating the incidence of paroxysmal atrial fibrillation in 10 patients with spontaneous or induced type 1 electrocardiographic pattern of Brugada syndrome (three with syncopal episodes and seven asymptomatic). Both clinical entities are closely associated with changes in autonomic modulation and, particularly, with increased vagal tone. METHODS: Transthoracic echocardiography, exercise treadmill test and 24-h Holter recordings were performed to all patients. RESULTS: Episodes of atrial fibrillation were recorded in 2/10 patients (20%). These patients suffered from syncopal episodes, exhibited a positive electrophysiological study, and finally received an implantable cardioverter-defibrillator. CONCLUSIONS: The present case series points out a high incidence of paroxysmal atrial fibrillation predominantly in symptomatic patients with type 1 electrocardiographic pattern of Brugada syndrome, indicating that the presence of atrial tachyarrhythmias may reflect an advanced stage of the disease. The prognostic significance of paroxysmal atrial fibrillation, particularly in asymptomatic patients with an electrocardiographic pattern consistent with Brugada syndrome requires further evaluation. Physicians should always be aware of Brugada syndrome in young patients with lone atrial fibrillation, especially in those with a history of syncope.
Konstantinos P Letsas; Antonios Sideris; Michalis Efremidis; Loukas K Pappas; Gerasimos Gavrielatos; Gerasimos S Filippatos; Fotis Kardaras
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  8     ISSN:  1558-2027     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-21     Completed Date:  2008-01-23     Revised Date:  2009-05-28    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  803-6     Citation Subset:  IM    
Second Department of Cardiology, Evangelismos General Hospital, Athens, Greece.
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MeSH Terms
Atrial Fibrillation / complications*,  epidemiology,  therapy
Brugada Syndrome / complications*,  physiopathology
Defibrillators, Implantable
Electrocardiography, Ambulatory
Exercise Test
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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