Document Detail

Prevalence of papillary microcarcinoma of the thyroid in Brazilian autopsy and surgical series.
MedLine Citation:
PMID:  17159249     Owner:  NLM     Status:  MEDLINE    
In order to search for parameters to differentiate patients at low and high risk for development of thyroid cancer, we studied thyroids from 166 consecutive autopsies and 261 thyroids that were surgically resected for thyroid diseases in general. We found 32 papillary microcarcinomas, corresponding to 7.8% of autopsies and 7.2% of surgical material, with a higher incidence between 30 and 49 yr of age. Both genders were similarly affected: 9.3% of the men and 8.8% of the women in autopsy series, and 6.2% of the men and 7.3% of the women in surgical series, suggesting that hormonal factors may favor the subsequent development of clinical lesions in women. Although associated nodular goiter has been observed in 54% of autopsies and 26% of surgical specimens, while Hashimoto's thyroiditis only in surgical material (15% of the cases), we were not able to correlate risk of malignancy with any concomitant lesion. The smallest papillary microcarcinomas presented most frequently as nonencapsulated nonsclerosing tumors without inflammatory infiltrate or fibrosis, suggesting that they may represent the early stages of development. Our data show a relatively high and similar frequency of papillary microcarcinomas in surgical and autopsy series, but do not demonstrate risk factors for clinical evolution.
Patrícia Sabino de Matos; Ana Paula C Ferreira; Laura S Ward
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine pathology     Volume:  17     ISSN:  1046-3976     ISO Abbreviation:  Endocr. Pathol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009288     Medline TA:  Endocr Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  165-73     Citation Subset:  IM    
Department of Pathology, School of Medicine FCM, State University of Campinas, Sao Paulo, Brazil.
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MeSH Terms
Brazil / epidemiology
Carcinoma, Papillary / complications,  epidemiology*,  pathology*
Risk Factors
Thyroid Diseases / complications
Thyroid Neoplasms / complications,  epidemiology*,  pathology*

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