| Prevalence of ocular surface disease in glaucoma patients. | |
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MedLine Citation:
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PMID: 18703943 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To examine the prevalence of ocular surface disease (OSD) in glaucoma patients. METHODS: This was a cross-sectional study. One hundred and one patients, 18 years of age or older, with open-angle glaucoma or ocular hypertension were consecutively recruited for the study. Patients with a history of use of cyclosporine, steroids, topical ocular nonsteroidal anti-inflammatory drugs, or punctal plugs within the last 3 months were excluded. Each patient completed an Ocular Surface Disease Index questionnaire and underwent evaluation by Schirmer test, corneal and conjunctival lissamine green staining, and tear break-up time. RESULTS: Using Ocular Surface Disease Index for measuring symptoms of dry eye, 60 (59%) patients reported symptoms in at least 1 eye. Severe symptoms were reported by 27 (27%) patients. Schirmer testing showed 62 (61%) patients with decrease in tear production in at least 1 eye. Severe tear deficiency was presented in 35 (35%) patients. Corneal and conjunctival lissamine green staining showed positive results in 22 (22%) patients. None had severe staining. Tear break-up time showed abnormal tear quality in 79 (78%) patients and severe decrease in tear quality was found in at least 1 eye in 66 (65%) patients. Multivariate logistic regression models were used to investigate the association between the number of benzalkonium chloride (BAK)-containing eyedrops and results on the clinical tests of OSD. After adjustment for age and sex, each additional BAK-containing eyedrop was associated with an approximately 2 times higher odds of showing abnormal results on the lissamine green staining test (odds ratio=2.03; 95% confidence interval: 1.06 to 3.89; P=0.034). CONCLUSION: A large proportion of patients with open-angle glaucoma or ocular hypertension had signs and/or symptoms of OSD in at least 1 eye. The coexistence of OSD and the use of BAK-containing medications may impact vision-related quality of life in this patient population. |
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Authors:
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Eamon W Leung; Felipe A Medeiros; Robert N Weinreb |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of glaucoma Volume: 17 ISSN: 1536-481X ISO Abbreviation: J. Glaucoma Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-15 Completed Date: 2008-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9300903 Medline TA: J Glaucoma Country: United States |
Other Details:
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Languages: eng Pagination: 350-5 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Hamilton Glaucoma Center, University of California, San Diego, La Jolla, CA 92093-0946, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antihypertensive Agents / administration & dosage Benzalkonium Compounds / administration & dosage Coloring Agents / metabolism Conjunctiva / metabolism Cornea / metabolism Cross-Sectional Studies Dry Eye Syndromes / epidemiology* Female Glaucoma, Open-Angle / drug therapy, epidemiology* Humans Intraocular Pressure Lissamine Green Dyes / metabolism Male Middle Aged Ocular Hypertension / drug therapy, epidemiology Preservatives, Pharmaceutical / administration & dosage Prevalence Questionnaires |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Benzalkonium Compounds; 0/Coloring Agents; 0/Lissamine Green Dyes; 0/Preservatives, Pharmaceutical |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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