Document Detail

Prevalence of ocular surface disease in glaucoma patients.
MedLine Citation:
PMID:  18703943     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To examine the prevalence of ocular surface disease (OSD) in glaucoma patients. METHODS: This was a cross-sectional study. One hundred and one patients, 18 years of age or older, with open-angle glaucoma or ocular hypertension were consecutively recruited for the study. Patients with a history of use of cyclosporine, steroids, topical ocular nonsteroidal anti-inflammatory drugs, or punctal plugs within the last 3 months were excluded. Each patient completed an Ocular Surface Disease Index questionnaire and underwent evaluation by Schirmer test, corneal and conjunctival lissamine green staining, and tear break-up time. RESULTS: Using Ocular Surface Disease Index for measuring symptoms of dry eye, 60 (59%) patients reported symptoms in at least 1 eye. Severe symptoms were reported by 27 (27%) patients. Schirmer testing showed 62 (61%) patients with decrease in tear production in at least 1 eye. Severe tear deficiency was presented in 35 (35%) patients. Corneal and conjunctival lissamine green staining showed positive results in 22 (22%) patients. None had severe staining. Tear break-up time showed abnormal tear quality in 79 (78%) patients and severe decrease in tear quality was found in at least 1 eye in 66 (65%) patients. Multivariate logistic regression models were used to investigate the association between the number of benzalkonium chloride (BAK)-containing eyedrops and results on the clinical tests of OSD. After adjustment for age and sex, each additional BAK-containing eyedrop was associated with an approximately 2 times higher odds of showing abnormal results on the lissamine green staining test (odds ratio=2.03; 95% confidence interval: 1.06 to 3.89; P=0.034). CONCLUSION: A large proportion of patients with open-angle glaucoma or ocular hypertension had signs and/or symptoms of OSD in at least 1 eye. The coexistence of OSD and the use of BAK-containing medications may impact vision-related quality of life in this patient population.
Eamon W Leung; Felipe A Medeiros; Robert N Weinreb
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of glaucoma     Volume:  17     ISSN:  1536-481X     ISO Abbreviation:  J. Glaucoma     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-15     Completed Date:  2008-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  350-5     Citation Subset:  IM    
Department of Ophthalmology, Hamilton Glaucoma Center, University of California, San Diego, La Jolla, CA 92093-0946, USA.
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MeSH Terms
Aged, 80 and over
Antihypertensive Agents / administration & dosage
Benzalkonium Compounds / administration & dosage
Coloring Agents / metabolism
Conjunctiva / metabolism
Cornea / metabolism
Cross-Sectional Studies
Dry Eye Syndromes / epidemiology*
Glaucoma, Open-Angle / drug therapy,  epidemiology*
Intraocular Pressure
Lissamine Green Dyes / metabolism
Middle Aged
Ocular Hypertension / drug therapy,  epidemiology
Preservatives, Pharmaceutical / administration & dosage
Reg. No./Substance:
0/Antihypertensive Agents; 0/Benzalkonium Compounds; 0/Coloring Agents; 0/Lissamine Green Dyes; 0/Preservatives, Pharmaceutical

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