Document Detail

Prevalence of nickel sensitization and urinary nickel content of children are increased by nickel in ambient air.
MedLine Citation:
PMID:  21168833     Owner:  NLM     Status:  In-Data-Review    
In a cross-sectional study performed in 2000, an unexpected positive association between nickel (Ni) in ambient air, urinary Ni content and the prevalence of Ni sensitization in a subgroup of 6-yr-old children living near a steel mill was observed. Between 2005 and 2006, in a different and larger study population, we examined if Ni from ambient air or urinary Ni concentration was related to Ni sensitization in children living next to Ni-emitting steel mills. We studied 749 school beginners living in four Ni-polluted industrial areas of North Rhine-Westphalia, Germany. We assessed Ni in ambient air, Ni in urine from children and mothers, and Ni in tap water, conducted patch tests in children (including the NiSO(4)-dilution test) and collected questionnaire data. Statistics were done by linear and logistic regression analyses, adjusted for covariates. At increased Ni concentration in ambient air (unit of increase: 10ng/m(3)), urinary Ni concentrations rose in both mothers (9.1%; 95% CI: 6.8-11.4%) and children (2.4%; 95% CI: 0.4-4.4%). The prevalence of Ni sensitization in children was associated with increased Ni from ambient air (unit of increase: 18ng/m(3); odds ratio 1.28; 95% CI: 1.25-1.32) and urinary Ni concentration (unit of increase: 7.1μg/L; odds ratio 2.4; 95% CI: 1.20-4.48). Ni in ambient air of areas with Ni-emitting factories contributes to internal Ni exposure in residents via inhalation and, furthermore, is a risk factor for the development of Ni sensitization in children.
Monika Kasper-Sonnenberg; Dorothee Sugiri; Sabine Wurzler; Ulrich Ranft; Heinrich Dickel; Jürgen Wittsiepe; Jürgen Hölzer; Friederike Lemm; Georg Eberwein; Peter Altmeyer; Martin Kraft; Ursula Krämer; Michael Wilhelm
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Publication Detail:
Type:  Journal Article     Date:  2010-12-18
Journal Detail:
Title:  Environmental research     Volume:  111     ISSN:  1096-0953     ISO Abbreviation:  Environ. Res.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum, Universitaetsstr. 150, 44780 Bochum, Germany.
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