| Prevalence of neuromuscular diseases in Chinese children: a study in southern China. | |
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MedLine Citation:
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PMID: 12731646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our objective was to study the prevalence of neuromuscular diseases in Chinese children. A prospective study of neuromuscular diseases in Chinese children was conducted from 1985 to 2001 in Hong Kong, which is a city in southern China. The population census of June 30, 2001, was used to calculate the prevalence of neuromuscular diseases in Chinese children. Altogether, 332 children aged < 19 years at first assessment with neuromuscular diseases confirmed by using electromyography, muscle biopsy, and/or molecular genetic study were included in the study. Of these, 228 (68%) had inherited and 104 (32%) had noninherited neuromuscular diseases. Of the inherited neuromuscular diseases, the most common were the dystrophinopathies, including Duchenne muscular dystrophy (n = 66) and Becker muscular dystrophy (n = 8). Spinal muscular atrophy was the second most common (n = 61). Of the noninherited neuromuscular disorders, myasthenia gravis was the most common (n = 62, 60%). Nearly 88% of the cases of myasthenia gravis were ocular type. The prevalence rate of neuromuscular diseases in June 2001 (n = 291 surviving) is estimated to be 214 x 10(-6). The estimated prevalence rate of neuromuscular diseases in our Chinese children is 1 in 4669. |
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Authors:
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Brian Chung; Virginia Wong; Patrick Ip |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of child neurology Volume: 18 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-05-06 Completed Date: 2003-07-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 217-9 Citation Subset: IM |
Affiliation:
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Department of Paediatrics & Adolescent Medicine, The University of Hong Kong, Pokfulam, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Biopsy Child Child, Preschool China / epidemiology Electromyography Female Humans Infant Infant, Newborn Male Neuromuscular Diseases / epidemiology* Prevalence Prospective Studies |
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