Document Detail


Prevalence of neuromuscular diseases in Chinese children: a study in southern China.
MedLine Citation:
PMID:  12731646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our objective was to study the prevalence of neuromuscular diseases in Chinese children. A prospective study of neuromuscular diseases in Chinese children was conducted from 1985 to 2001 in Hong Kong, which is a city in southern China. The population census of June 30, 2001, was used to calculate the prevalence of neuromuscular diseases in Chinese children. Altogether, 332 children aged < 19 years at first assessment with neuromuscular diseases confirmed by using electromyography, muscle biopsy, and/or molecular genetic study were included in the study. Of these, 228 (68%) had inherited and 104 (32%) had noninherited neuromuscular diseases. Of the inherited neuromuscular diseases, the most common were the dystrophinopathies, including Duchenne muscular dystrophy (n = 66) and Becker muscular dystrophy (n = 8). Spinal muscular atrophy was the second most common (n = 61). Of the noninherited neuromuscular disorders, myasthenia gravis was the most common (n = 62, 60%). Nearly 88% of the cases of myasthenia gravis were ocular type. The prevalence rate of neuromuscular diseases in June 2001 (n = 291 surviving) is estimated to be 214 x 10(-6). The estimated prevalence rate of neuromuscular diseases in our Chinese children is 1 in 4669.
Authors:
Brian Chung; Virginia Wong; Patrick Ip
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of child neurology     Volume:  18     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-05-06     Completed Date:  2003-07-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  217-9     Citation Subset:  IM    
Affiliation:
Department of Paediatrics & Adolescent Medicine, The University of Hong Kong, Pokfulam, China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Biopsy
Child
Child, Preschool
China / epidemiology
Electromyography
Female
Humans
Infant
Infant, Newborn
Male
Neuromuscular Diseases / epidemiology*
Prevalence
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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