Document Detail


Prevalence of monoclonal gammopathy of undetermined significance in Thailand.
MedLine Citation:
PMID:  22234527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Individuals with monoclonal gammopathy of undetermined significance (MGUS) develop multiple myeloma and related malignancies at the rate of 1% per year. Given differences in ethnicity, data on prevalence and risk factors of MGUS in Thai population will be helpful in understanding the pathogenesis of plasma cell disorders and designing an early cancer detection strategy. Subjects of 50 years or older were included. Demographic data and suspected risk factors were collected. Monoclonal proteins were detected using serum protein electrophoresis. Serum was obtained from 3,260 participants; 1,104 males (33.9%) and 2,156 females (66.1%). The median age was 57 years (range 50-93 years). Monoclonal proteins were detectable in 2.3% (95% confidence interval [CI] 1.8-2.8). M spikes were found in gamma- and beta-globulin regions in 50 (1.5%) and 25 (0.8%) subjects, respectively. The prevalence of MGUS in subjects 50-59, 60-69, and 70 years or older was 2.0% (41/1,975), 2.6% (22/851), and 2.8% (12/434), respectively. By multivariate analysis, MGUS was associated with living outside Bangkok (odds ratio 2.25, 95% CI 1.11-4.58). The overall prevalence of MGUS in the Thai population was 2.3%, which was lower than that in Western countries, but comparable to that in Japan.
Authors:
Phandee Watanaboonyongcharoen; Thanyaphong Na Nakorn; Ponlapat Rojnuckarin; Panisinee Lawasut; Tanin Intragumtornchai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-12
Journal Detail:
Title:  International journal of hematology     Volume:  95     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-21     Completed Date:  2012-06-26     Revised Date:  2012-09-11    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  176-81     Citation Subset:  IM    
Affiliation:
Transfusion Medicine Unit, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Aged
Asian Continental Ancestry Group / statistics & numerical data*
Beta-Globulins / metabolism
Female
Glycoproteins / blood
Humans
Immunoglobulin A / blood
Immunoglobulin G / blood
Immunoglobulin kappa-Chains / blood
Immunoglobulin lambda-Chains / blood
Male
Middle Aged
Monoclonal Gammopathy of Undetermined Significance / blood*,  ethnology*
Multiple Myeloma / ethnology
Prevalence
Risk Factors
Thailand / epidemiology
gamma-Globulins / metabolism
Chemical
Reg. No./Substance:
0/Beta-Globulins; 0/Glycoproteins; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin kappa-Chains; 0/Immunoglobulin lambda-Chains; 0/gamma-Globulins; 0/protein M (glycoprotein)
Comments/Corrections
Comment In:
Int J Hematol. 2012 Jul;96(1):144-5   [PMID:  22661012 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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