Document Detail

Prevalence of monoclonal gammopathy in patients with primary hyperparathyroidism: a prospective study.
MedLine Citation:
PMID:  11863481     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The association between primary hyperparathyroidism (PHPT) and monoclonal gammopathy has been reported, but whether it is fortuitous remains unsettled. We conducted a prospective study to determine the prevalence of monoclonal gammopathies in patients with surgically proved PHPT. METHODS: In 101 consecutive patients with PHPT, serum immunoglobulins were systematically studied using agarose gel electrophoresis and immunofixation before and, when appropriate, after parathyroid surgery. The PHPT population was compared with a control series of patients with other diseases requiring surgery and with a group of patients with benign disease of the thyroid gland matched for age and sex to the PHPT population. RESULTS: Monoclonal immunoglobulin was detected in 10 (10%) of 101 patients with PHPT (including 2 with multiple myeloma) compared with 2 (2%) of 127 patients who underwent other surgery (P =.005) and 3 (3%) of 101 patients with benign thyroid diseases (P =.04). CONCLUSIONS: The prevalence of monoclonal gammopathies is high in patients with PHPT. At minimum, sensitive serum protein electrophoresis should be performed routinely in all patients with PHPT. Conversely, in patients with monoclonal gammopathy who have hypercalcemia but no other symptoms of progressive disease, clinicians must seek PHPT.
Bertrand Arnulf; Djaouida Bengoufa; Emile Sarfati; Marie-Elisabeth Toubert; Véronique Meignin; Jean-Claude Brouet; Jean-Paul Fermand
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  162     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-26     Completed Date:  2002-03-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  464-7     Citation Subset:  AIM; IM    
Service d'Immuno-Hématologie, Hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75475 Paris, Cedex 10, France.
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MeSH Terms
Aged, 80 and over
Hyperparathyroidism / blood,  complications*,  surgery
Immunoglobulins / blood
Middle Aged
Paraproteinemias / blood,  complications*
Prospective Studies
Reg. No./Substance:

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