Document Detail


Prevalence of monoclonal gammopathy in patients with primary hyperparathyroidism: a prospective study.
MedLine Citation:
PMID:  11863481     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The association between primary hyperparathyroidism (PHPT) and monoclonal gammopathy has been reported, but whether it is fortuitous remains unsettled. We conducted a prospective study to determine the prevalence of monoclonal gammopathies in patients with surgically proved PHPT. METHODS: In 101 consecutive patients with PHPT, serum immunoglobulins were systematically studied using agarose gel electrophoresis and immunofixation before and, when appropriate, after parathyroid surgery. The PHPT population was compared with a control series of patients with other diseases requiring surgery and with a group of patients with benign disease of the thyroid gland matched for age and sex to the PHPT population. RESULTS: Monoclonal immunoglobulin was detected in 10 (10%) of 101 patients with PHPT (including 2 with multiple myeloma) compared with 2 (2%) of 127 patients who underwent other surgery (P =.005) and 3 (3%) of 101 patients with benign thyroid diseases (P =.04). CONCLUSIONS: The prevalence of monoclonal gammopathies is high in patients with PHPT. At minimum, sensitive serum protein electrophoresis should be performed routinely in all patients with PHPT. Conversely, in patients with monoclonal gammopathy who have hypercalcemia but no other symptoms of progressive disease, clinicians must seek PHPT.
Authors:
Bertrand Arnulf; Djaouida Bengoufa; Emile Sarfati; Marie-Elisabeth Toubert; Véronique Meignin; Jean-Claude Brouet; Jean-Paul Fermand
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  162     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-26     Completed Date:  2002-03-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  464-7     Citation Subset:  AIM; IM    
Affiliation:
Service d'Immuno-Hématologie, Hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75475 Paris, Cedex 10, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Female
Humans
Hyperparathyroidism / blood,  complications*,  surgery
Immunoglobulins / blood
Male
Middle Aged
Paraproteinemias / blood,  complications*
Prospective Studies
Chemical
Reg. No./Substance:
0/Immunoglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Delirium predicts 12-month mortality.
Next Document:  Impact of a targeted intervention on lipid-lowering therapy in patients with coronary artery disease...