| Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging. | |
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MedLine Citation:
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PMID: 20820000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We investigated the prevalence of mild cognitive impairment (MCI) in Olmsted County, MN, using in-person evaluations and published criteria. METHODS: We evaluated an age- and sex-stratified random sample of Olmsted County residents who were 70-89 years old on October 1, 2004, using the Clinical Dementia Rating Scale, a neurologic evaluation, and neuropsychological testing to assess 4 cognitive domains: memory, executive function, language, and visuospatial skills. Information for each participant was reviewed by an adjudication panel and a diagnosis of normal cognition, MCI, or dementia was made using published criteria. RESULTS: Among 1,969 subjects without dementia, 329 subjects had MCI, with a prevalence of 16.0% (95% confidence interval [CI] 14.4-17.5) for any MCI, 11.1% (95% CI 9.8-12.3) for amnestic MCI, and 4.9% (95% CI 4.0-5.8) for nonamnestic MCI. The prevalence of MCI increased with age and was higher in men. The prevalence odds ratio (OR) in men was 1.54 (95% CI 1.21-1.96; adjusted for age, education, and nonparticipation). The prevalence was also higher in subjects who never married and in subjects with an APOE epsilon3epsilon4 or epsilon4epsilon4 genotype. MCI prevalence decreased with increasing number of years of education (p for linear trend <0.0001). CONCLUSIONS: Our study suggests that approximately 16% of elderly subjects free of dementia are affected by MCI, and amnestic MCI is the most common type. The higher prevalence of MCI in men may suggest that women transition from normal cognition directly to dementia at a later age but more abruptly. |
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Authors:
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R C Petersen; R O Roberts; D S Knopman; Y E Geda; R H Cha; V S Pankratz; B F Boeve; E G Tangalos; R J Ivnik; W A Rocca |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 75 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-07 Completed Date: 2010-09-27 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 889-97 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. peter8@mayo.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aging Cognition Disorders / diagnosis, epidemiology* Dementia / diagnosis, epidemiology* Executive Function Female Humans Male Minnesota Neuropsychological Tests Odds Ratio Prevalence Sex Characteristics* Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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K01 AG028573/AG/NIA NIH HHS; K01 MH068351/MH/NIMH NIH HHS; P50 AG016574/AG/NIA NIH HHS; R01 AG034676-46/AG/NIA NIH HHS; R01 AR030582-44/AR/NIAMS NIH HHS; R01AR030582/AR/NIAMS NIH HHS; U01 AG006786/AG/NIA NIH HHS |
| Comments/Corrections | |
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