Document Detail

Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging.
MedLine Citation:
PMID:  20820000     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We investigated the prevalence of mild cognitive impairment (MCI) in Olmsted County, MN, using in-person evaluations and published criteria.
METHODS: We evaluated an age- and sex-stratified random sample of Olmsted County residents who were 70-89 years old on October 1, 2004, using the Clinical Dementia Rating Scale, a neurologic evaluation, and neuropsychological testing to assess 4 cognitive domains: memory, executive function, language, and visuospatial skills. Information for each participant was reviewed by an adjudication panel and a diagnosis of normal cognition, MCI, or dementia was made using published criteria.
RESULTS: Among 1,969 subjects without dementia, 329 subjects had MCI, with a prevalence of 16.0% (95% confidence interval [CI] 14.4-17.5) for any MCI, 11.1% (95% CI 9.8-12.3) for amnestic MCI, and 4.9% (95% CI 4.0-5.8) for nonamnestic MCI. The prevalence of MCI increased with age and was higher in men. The prevalence odds ratio (OR) in men was 1.54 (95% CI 1.21-1.96; adjusted for age, education, and nonparticipation). The prevalence was also higher in subjects who never married and in subjects with an APOE epsilon3epsilon4 or epsilon4epsilon4 genotype. MCI prevalence decreased with increasing number of years of education (p for linear trend <0.0001).
CONCLUSIONS: Our study suggests that approximately 16% of elderly subjects free of dementia are affected by MCI, and amnestic MCI is the most common type. The higher prevalence of MCI in men may suggest that women transition from normal cognition directly to dementia at a later age but more abruptly.
R C Petersen; R O Roberts; D S Knopman; Y E Geda; R H Cha; V S Pankratz; B F Boeve; E G Tangalos; R J Ivnik; W A Rocca
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  75     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-07     Completed Date:  2010-09-27     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  889-97     Citation Subset:  AIM; IM    
Department of Neurology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
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MeSH Terms
Aged, 80 and over
Cognition Disorders / diagnosis,  epidemiology*
Dementia / diagnosis,  epidemiology*
Executive Function
Neuropsychological Tests
Odds Ratio
Sex Characteristics*
Sex Factors
Grant Support
K01 AG028573/AG/NIA NIH HHS; K01 MH068351/MH/NIMH NIH HHS; P50 AG016574/AG/NIA NIH HHS; R01 AG034676-46/AG/NIA NIH HHS; R01 AR030582-44/AR/NIAMS NIH HHS; R01AR030582/AR/NIAMS NIH HHS; U01 AG006786/AG/NIA NIH HHS

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