Document Detail

Prevalence of microalbuminuria in a large population of patients with mild to moderate essential hypertension.
MedLine Citation:
PMID:  1528348     Owner:  NLM     Status:  MEDLINE    
To determine the prevalence of increased urinary albumin excretion (UAE) in essential hypertension and to establish whether this abnormality is associated with deranged renal function, we have measured UAE in a group of 123 patients with essential hypertension and in 110 normal subjects. Mean arterial pressure (MAP) was 96 +/- 0.6 mm Hg in normal subjects and 121 +/- 0.3 mm Hg in patients with essential hypertension (p less than 0.01). Mean UAE was 8.6 +/- 0.5 in normal subjects and 32.9 +/- 3.3 mg/24 h in patients with essential hypertension (p less than 0.01). Forty percent of patients with essential hypertension manifested a UAE exceeding 30 mg/24 h and had an average UAE of 72.0 +/- 4.7 mg/24 h. MAP in patients with increased UAE was similar to that in subjects with normal UAE (121 +/- 0.5 vs. 121 +/- 0.4 mm Hg). Creatinine clearance was also not different between these two groups (91 +/- 1.8 vs. 94 +/- 1.5 ml/min). No correlation was found between UAE and MAP or creatinine clearance. Long-term prospective studies are needed to extablish whether an increase in UAE may predict future nephrosclerosis in essential hypertension.
R Bigazzi; S Bianchi; V M Campese; G Baldari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  61     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-20     Completed Date:  1992-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  94-7     Citation Subset:  IM    
Nephrology and Dialysis Unit, Ospedali Riuniti Livorno, Italy.
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MeSH Terms
Albuminuria* / epidemiology
Biological Markers / urine
Blood Pressure
Hypertension / physiopathology*,  urine
Middle Aged
Reference Values
Risk Factors
Reg. No./Substance:
0/Biological Markers
Erratum In:
Nephron 1992;62(1):120

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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