| Prevalence of microalbuminuria in a large population of patients with mild to moderate essential hypertension. | |
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MedLine Citation:
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PMID: 1528348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the prevalence of increased urinary albumin excretion (UAE) in essential hypertension and to establish whether this abnormality is associated with deranged renal function, we have measured UAE in a group of 123 patients with essential hypertension and in 110 normal subjects. Mean arterial pressure (MAP) was 96 +/- 0.6 mm Hg in normal subjects and 121 +/- 0.3 mm Hg in patients with essential hypertension (p less than 0.01). Mean UAE was 8.6 +/- 0.5 in normal subjects and 32.9 +/- 3.3 mg/24 h in patients with essential hypertension (p less than 0.01). Forty percent of patients with essential hypertension manifested a UAE exceeding 30 mg/24 h and had an average UAE of 72.0 +/- 4.7 mg/24 h. MAP in patients with increased UAE was similar to that in subjects with normal UAE (121 +/- 0.5 vs. 121 +/- 0.4 mm Hg). Creatinine clearance was also not different between these two groups (91 +/- 1.8 vs. 94 +/- 1.5 ml/min). No correlation was found between UAE and MAP or creatinine clearance. Long-term prospective studies are needed to extablish whether an increase in UAE may predict future nephrosclerosis in essential hypertension. |
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Authors:
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R Bigazzi; S Bianchi; V M Campese; G Baldari |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nephron Volume: 61 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1992 |
Date Detail:
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Created Date: 1992-10-20 Completed Date: 1992-10-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 94-7 Citation Subset: IM |
Affiliation:
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Nephrology and Dialysis Unit, Ospedali Riuniti Livorno, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albuminuria*
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epidemiology Biological Markers / urine Blood Pressure Female Humans Hypertension / physiopathology*, urine Male Middle Aged Prevalence Reference Values Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
Erratum In:
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Nephron 1992;62(1):120 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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