Document Detail


Prevalence of microalbuminuria in a large population of patients with mild to moderate essential hypertension.
MedLine Citation:
PMID:  1528348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the prevalence of increased urinary albumin excretion (UAE) in essential hypertension and to establish whether this abnormality is associated with deranged renal function, we have measured UAE in a group of 123 patients with essential hypertension and in 110 normal subjects. Mean arterial pressure (MAP) was 96 +/- 0.6 mm Hg in normal subjects and 121 +/- 0.3 mm Hg in patients with essential hypertension (p less than 0.01). Mean UAE was 8.6 +/- 0.5 in normal subjects and 32.9 +/- 3.3 mg/24 h in patients with essential hypertension (p less than 0.01). Forty percent of patients with essential hypertension manifested a UAE exceeding 30 mg/24 h and had an average UAE of 72.0 +/- 4.7 mg/24 h. MAP in patients with increased UAE was similar to that in subjects with normal UAE (121 +/- 0.5 vs. 121 +/- 0.4 mm Hg). Creatinine clearance was also not different between these two groups (91 +/- 1.8 vs. 94 +/- 1.5 ml/min). No correlation was found between UAE and MAP or creatinine clearance. Long-term prospective studies are needed to extablish whether an increase in UAE may predict future nephrosclerosis in essential hypertension.
Authors:
R Bigazzi; S Bianchi; V M Campese; G Baldari
Related Documents :
2915738 - Hypokalaemia in hypertensive patients treated with diuretics: no increase in cardiac ar...
1889858 - Are vascular abnormalities a primary cause or secondary consequence of hypertension?
1772328 - Early toxicity of recombinant interleukin-2 in cats.
3207158 - Comparison of vertical fixation disparities between essential hypertensives and matched...
11880018 - Application of nasal bi-level positive airway pressure to respiratory support during co...
11713898 - Commentary on treatment of hypertension in the elderly.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  61     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-20     Completed Date:  1992-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  94-7     Citation Subset:  IM    
Affiliation:
Nephrology and Dialysis Unit, Ospedali Riuniti Livorno, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Albuminuria* / epidemiology
Biological Markers / urine
Blood Pressure
Female
Humans
Hypertension / physiopathology*,  urine
Male
Middle Aged
Prevalence
Reference Values
Risk Factors
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections
Erratum In:
Nephron 1992;62(1):120

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intracellular free magnesium of red blood cells in patients with renal disease.
Next Document:  Renal transplant artery rupture secondary to candida infection.