| Prevalence of mechanical dyssynchrony in patients with heart failure and preserved left ventricular function (a report from the Belgian Multicenter Registry on dyssynchrony). | |
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MedLine Citation:
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PMID: 16310437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study evaluated the prevalence of mechanical inter- and intraventricular dyssynchrony in patients with heart failure and preserved left ventricular (LV) ejection fraction (LVEF). We studied 138 patients with heart failure (age 67+/-11 years; 76% men); 60 patients had preserved LVEF (>40%). Using conventional Doppler echocardiography, an interventricular mechanical delay>or=40 ms was defined as interventricular dyssynchrony. Using pulse-wave tissue Doppler imaging, the time from the beginning of the QRS complex to onset of systolic motion was measured in 4 basal LV segments. A dispersion of >or=60 ms was defined as intraventricular dyssynchrony. The prevalence of inter- and intraventricular dyssynchrony was lower in patients with preserved LVEF than in those with reduced LVEF (17% vs 41%, p<0.01 for interventricular dyssynchrony, 18% vs 36%, p<0.01 for intraventricular dyssynchrony). However, patients with preserved LVEF and a QRS width>or=120 ms had higher values for the parameters for inter- and intraventricular dyssynchrony than patients with a QRS width<120 ms (interventricular mechanical delay 33+/-20 vs 20+/-16 ms, p<0.05; tissue Doppler imaging dispersion 42+/-26 vs 33+/-22 ms, p<0.05). In patients with a QRS width>or=120 ms, the prevalence of inter- and intraventricular dyssynchrony was comparable for patients with preserved and reduced LVEF (42% vs 55%, p=NS for interventricular dyssynchrony and 45% vs 46%, p=NS for intraventricular dyssynchrony). In conclusion, the prevalence of inter- and intraventricular dyssynchrony was low (17% and 18%, respectively) in patients with heart failure and preserved LVEF. However, in the presence of a QRS width of >or=120 ms, this prevalence increased to almost 50%, comparable to that for patients with heart failure and reduced LVEF and a QRS width of >or=120 ms. |
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Authors:
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Johan De Sutter; Nico R Van de Veire; Luc Muyldermans; Tine De Backer; Etienne Hoffer; Marc Vaerenberg; Bernard Paelinck; Pierre Decoodt; Laurence Gabriel; Thierry C Gillebert; Guy Van Camp; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study Date: 2005-10-19 |
Journal Detail:
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Title: The American journal of cardiology Volume: 96 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-28 Completed Date: 2006-01-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1543-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiovascular Diseases, Ghent University, Gent, Belgium. johan.desutter@Ugent.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Disease Progression Echocardiography, Doppler, Pulsed Electrocardiography Female Heart Block / epidemiology, etiology*, physiopathology Heart Failure / complications*, physiopathology, ultrasonography Heart Rate Humans Male Middle Aged Prevalence Retrospective Studies Risk Factors Stroke Volume / physiology Ventricular Function, Left / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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