Document Detail

Prevalence of maternal vitamin D deficiency in neonates with delayed hypocalcaemia.
MedLine Citation:
PMID:  23292625     Owner:  NLM     Status:  MEDLINE    
Maternal vitamin D deficiency is one of the major risk factors for neonatal vitamin D deficiency followed by neonatal hypocalcaemia. The aim of this study is to determine the relationship between delayed neonatal hypocalcaemia and maternal vitamin D deficiency. This is a descriptive cross-sectional study. Target population of this study included all term and preterm neonates with delayed hypocalcaemia (after the first 72 hours of birth) admitted to Ali-Asghar Hospital. The sample size was 100 neonates included in the study. Demographic, clinical and paraclinical data including Ca, P, PTH and level of maternal and neonatal vitamin D were recorded according to patients records. 67 neonates (67%) were term and 33(33%) were preterm neonates. The mean of serum calcium in neonates was 6.49± 0.68mg/dL (in the range of 4.3-7.8 mg/dL). 85% of neonates and 74% of mothers had vitamin D deficiency. 100% of neonates born to mothers with vitamin D deficiency were hypocalcaemia. A statistically significant difference was seen between the mean values of serum Ca (6.67 in term vs. 6.12 in preterm neonates) and vitamin D in term and preterm neonates was 16.34 vs. 20.18 (P= 0.0001 and P=0.01 respectively). Also, a significant correlation was seen between maternal and neonatal level of vitamin D (P=0.0001, r=0.789). With regard to the socio-cultural status in Iran besides women's clothing style and nutritional deficiencies before and during pregnancy, health authorities and policy makers are responsible to focus their serious attention on hypocalcaemia and hypovitaminosis D in neonates.
Nassrin Khalesi; Seyed Mohsen Bahaeddini; Mamak Shariat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Iranica     Volume:  50     ISSN:  1735-9694     ISO Abbreviation:  Acta Med Iran     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-07-19     Revised Date:  2014-09-30    
Medline Journal Info:
Nlm Unique ID:  14540050R     Medline TA:  Acta Med Iran     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  740-5     Citation Subset:  IM    
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MeSH Terms
Alkaline Phosphatase / blood
Biological Markers / blood*
Birth Weight
Bone Density Conservation Agents / blood
Calcifediol / blood
Calcium / blood
Cross-Sectional Studies
Hypocalcemia / blood,  diagnosis*,  epidemiology,  etiology
Infant, Newborn
Iran / epidemiology
Magnesium / blood
Maternal-Fetal Exchange
Parathyroid Hormone / blood
Phosphorus / blood
Risk Factors
Sample Size
Vitamin D Deficiency / blood,  complications,  diagnosis*,  epidemiology
Reg. No./Substance:
0/Biological Markers; 0/Bone Density Conservation Agents; 0/Parathyroid Hormone; 27YLU75U4W/Phosphorus; EC Phosphatase; I38ZP9992A/Magnesium; P6YZ13C99Q/Calcifediol; SY7Q814VUP/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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