Document Detail


Prevalence of latent tuberculosis infection among gold miners in South Africa.
MedLine Citation:
PMID:  19105877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SETTING: South African gold mines.
OBJECTIVE: To determine the prevalence of latent tuberculosis infection (LTBI) and risk factors for a positive tuberculin skin test (TST) among gold miners.
DESIGN: Cross-sectional survey. Human immunodeficiency virus (HIV) status was determined by self-report and medical records. TST positivity was defined by the mirror method to estimate the prevalence of LTBI, and by the US Centers for Disease Control and Prevention definitions to explore risk factors at the individual level.
RESULTS: Among 429 participants (105/130 subjects aged <30 years, 324/390 > or = 30 years), the estimated prevalence of LTBI was 89%; 45.5% of HIV-positive participants had a zero TST response compared to respectively 13% and 13.5% in the HIV-negative and status unknown participants. In participants with TST > 0, there was no significant difference between size of response by HIV status: the mean (standard deviation) widths for HIV-positive, HIV-negative and HIV status unknown were respectively 11.84 (2.75), 12.03 (2.75) and 12.52 mm (3.04) (analysis of variance P = 0.28). Factors independently associated with a TST < 10 mm were positive HIV status (aOR 0.41, 95%CI 0.17-0.96) and not working underground (aOR 0.25, 95%CI 0.09-0.71).
CONCLUSIONS: The prevalence of LTBI is very high in gold miners in South Africa. HIV-infected individuals are more likely to have a negative TST, but HIV infection does not affect the size of TST response.
Authors:
Y Hanifa; A D Grant; J Lewis; E L Corbett; K Fielding; G Churchyard
Related Documents :
19996347 - Hiv prevalence and testing practices among tuberculosis cases in london: a missed oppor...
16209227 - Extraspinal osteoarticular tuberculosis: a forgotten entity?
19839287 - The feasibility of using an 'opt-out' approach to achieve universal hiv testing of tube...
22160887 - Molecular genetic analysis of mycobacterium tuberculosis strains spread in different pa...
12170307 - Chronic infection with hepatitis and herpes viruses in patients with sjogren's disease.
18449067 - Resolution of human immunodeficiency virus type 1 infection-related severe pulmonary hy...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  13     ISSN:  1027-3719     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-24     Completed Date:  2009-03-12     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Comorbidity
Cross-Sectional Studies
Female
Gold
HIV Infections / epidemiology
Humans
Male
Middle Aged
Mining*
Occupational Diseases / epidemiology*
Prevalence
South Africa / epidemiology
Tuberculin Test
Tuberculosis / epidemiology*
Grant Support
ID/Acronym/Agency:
G0700837//Medical Research Council; //Department of Health
Chemical
Reg. No./Substance:
7440-57-5/Gold

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Annual risks of tuberculous infection in East Nusa Tenggara and Central Java Provinces, Indonesia.
Next Document:  A simple screening tool for active tuberculosis in HIV-infected adults receiving antiretroviral trea...