| Prevalence and intensity of Wuchereria bancrofti antigenaemia in Sri Lanka by Og4C3 ELISA using filter paper-absorbed whole blood. | |
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MedLine Citation:
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PMID: 11925989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In Sri Lanka 2741 people from Matara, an endemic area for Wuchereria bancrofti, were examined in 1996/97 for microfilariae by 60-microL blood smear and for circulating filarial antigens by Og4C3 ELISA using filter paper-absorbed whole blood. The overall prevalence of microfilaraemia was 3.4%, and that of antigenaemia 14.4%. The prevalence of antigen-positive and microfilaria-negative people was 11.3%. Analysed by age-group, antigenaemia prevalence was similar in all groups, and the average number of antigen units was already very high in the age-group < 10 years, indicating that the infection started in early childhood. Among those who were antigen positive, the microfilaria prevalence was lower in females than in males. Diethylcarbamazine treatment eliminated microfilariae in 78% of the positives. However, 17 months after the treatment, antigenaemia was still positive in 76% of those who were parasitologically cured. |
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Authors:
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M V Weerasooriya; N K Gunawardena; M Itoh; X G Qiu; E Kimura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transactions of the Royal Society of Tropical Medicine and Hygiene Volume: 96 ISSN: 0035-9203 ISO Abbreviation: Trans. R. Soc. Trop. Med. Hyg. Publication Date: 2002 Jan-Feb |
Date Detail:
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Created Date: 2002-04-02 Completed Date: 2002-05-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506129 Medline TA: Trans R Soc Trop Med Hyg Country: England |
Other Details:
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Languages: eng Pagination: 41-5 Citation Subset: IM |
Affiliation:
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Filariasis Research Unit, Department of Parasitology, Faculty of Medicine, University of Ruhuna, P. O. Box 70, Galle, Sri Lanka. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analysis of Variance Animals Antigens, Helminth / blood* Child Child, Preschool Diethylcarbamazine / therapeutic use Enzyme-Linked Immunosorbent Assay / methods Female Filariasis / drug therapy, epidemiology*, immunology Filaricides / therapeutic use Humans Infant Infant, Newborn Male Middle Aged Prevalence Sri Lanka / epidemiology Wuchereria bancrofti / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Helminth; 0/Filaricides; 90-89-1/Diethylcarbamazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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