Document Detail


Prevalence of inflammatory bowel disease related dysplasia and cancer in 1500 colonoscopies from a referral center in northwestern Greece.
MedLine Citation:
PMID:  21272799     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND AND AIM: To report on the prevalence of inflammatory bowel disease (IBD) related intestinal dysplasia and cancer in northwestern Greece.
PATIENTS AND METHODS: Single referral center retrospective study. The policy among all gastroenterologists of the area regarding medical treatment, patient follow up and bowel surveillance strategies including risk factors is the same.
RESULTS: We analyzed 1494 colonoscopies from 696 consecutive IBD patients (494 UC). The follow up time [median, IQR] was 16 [8-23] years and the age at diagnosis was 28 [21-49] years. The number of patient years at risk was 16.219. Disease location for UC was: pancolitis 761 (59%), left sided colitis 455 (35%), and proctitis 69 (6%). Disease location for CD was: colitis 142 (66%), ilieitis 45 (22%) and ileocolitis 21 (10%). Disease activity was in remission in 1240 (83%) of them. In total, 498 (72%) patients were on mesalazine, 169(24%) on immunosuppression and 29 (4%) on biologicals. Biopsies were taken randomly in 1429 (96%) endoscopies and were targeted in 65 (4%) of them. We recorded 69 (9.4%) cases with dysplasia and 10 (1.4%) cases with intestinal cancer (9 in UC). No difference was found for dysplasia and cancer in patients who followed up for 10-20years or for more than 20years.
CONCLUSIONS: The prevalence of dysplasia and cancer is increased in UC compared to CD but the prevalence of high-grade dysplasia is comparatively low. Intestinal cancer prevalence is increasing after the first decade and then practically remains stable.
Authors:
Konstantinos H Katsanos; Paraskevi Stamou; Athina Tatsioni; Vasileios E Tsianos; Stefanos Zoumbas; Spyridoula Kavvadia; Anna Giga; Ioannis Vagias; Dimitrios K Christodoulou; Epameinondas V Tsianos; On Behalf Of The Northwest Greece Ibd Study Group
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Publication Detail:
Type:  Journal Article     Date:  2010-12-18
Journal Detail:
Title:  Journal of Crohn's & colitis     Volume:  5     ISSN:  1876-4479     ISO Abbreviation:  J Crohns Colitis     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101318676     Medline TA:  J Crohns Colitis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  19-23     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
Affiliation:
1st Department of Internal Medicine & Hepato-Gastroenterology Unit, University Hospital of Ioannina, Greece.
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