Document Detail

Prevalence, incidence, and mother-to-child transmission of HIV-1 in rural South Africa.
MedLine Citation:
PMID:  12241784     Owner:  NLM     Status:  MEDLINE    
Simple, robust approaches are needed to monitor prevalence, incidence, and mother-to-child transmission of HIV-1 in rural Africa. We have designed a method that uses antibody and viral RNA testing of dried blood spots obtained from mother-infant pairs attending routine immunisation clinics. In our study, prevalence and incidence of HIV-1 was highest in young women in their late teens and early twenties. In children born to infected mothers, prevalence increased from 14% in infants younger than 6 weeks of age to 24% at 3-6 months. The blood-spot approach is an effective method for surveillance of HIV-1 in women and children, and for early identification of incidence of this infection in women of child-bearing age.
N C Rollins; M Dedicoat; S Danaviah; T Page; K Bishop; I Kleinschmidt; H M Coovadia; S A Cassol;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  360     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-20     Completed Date:  2002-10-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  389     Citation Subset:  AIM; IM    
Africa Centre for Health and Population Studies, KwaZulu, Natal, South Africa.
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MeSH Terms
HIV Infections / diagnosis,  epidemiology,  transmission*
Infant, Newborn
Infectious Disease Transmission, Vertical*
Rural Health*
South Africa / epidemiology

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