| Prevalence and incidence of microscopic colitis in patients with diarrhoea of unknown aetiology in a region in central Spain. | |
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MedLine Citation:
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PMID: 22265684 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Often previously overlooked, microscopic colitis, including collagenous colitis and lymphocytic colitis, has now emerged as a common cause of chronic diarrhoea. AIMS: To evaluate the prevalence and incidence of microscopic colitis in patients with diarrhoea of unknown aetiology. METHODS: 271 consecutive patients who were referred to the General Hospital of Tomelloso from April 2008 to December 2010 for diarrhoea of unknown aetiology underwent a full colonoscopy to obtain biopsy samples to diagnose microscopic colitis on the basis of commonly accepted histological criteria. All patients were classified according to the Roma III criteria for diarrhoea-dominant irritable bowel syndrome. RESULTS: In 234/271 consecutive patients with normal endoscopic appearance we observed 32/234 patients with microscopic colitis (30 lymphocytic colitis and 2 collagenous colitis) with a prevalence of microscopic colitis of 48 cases/100,000 inhabitants (95%CI: 30-65) and mean annual standardised incidence of 18 cases/100,000 inhabitants (95%CI: 16.0-20.0). Analysing only the patients that met the Roma III criteria (84/271), we observed 10.7% microscopic colitis diagnosis, with higher risk in the presence of autoimmune disease, seronegative celiac disease and intake of non-steroidal anti-inflammatory drugs. CONCLUSIONS: Microscopic colitis was found in 13.7% of patients with chronic diarrhoea. Microscopic colitis is present in a relevant proportion of symptomatic patients meeting diagnostic criteria for irritable bowel syndrome (10.7%). |
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Authors:
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Danila Guagnozzi; Alfredo J Lucendo; Teresa Angueira-Lapeña; Sonia González-Castillo; José Maria Tenias Burillo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-19 |
Journal Detail:
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Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: - ISSN: 1878-3562 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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