| Prevalence of hypopituitarism in patients with cerebrovascular diseases. | |
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MedLine Citation:
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PMID: 19020380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stroke is one of the main causes of death and disability in the adult population. Changes in pituitary hormone secretion may be observed during the acute phase of stroke, representing part of the adaptive response to injury. However, reduced pituitary hormone secretion, caused by pituitary and/or hypothalamus damage, may also occur. Hypopituitarism has been observed in 19% of patients with ischemic stroke and 47% of patients with subarachnoid hemorrhage, presenting as an isolated deficiency in most cases. Diabetes insipidus is very rare. Low IGF-I levels, during the acute phase of stroke, have been associated with poor outcome and high mortality. During rehabilitation, higher IGF-I levels have been observed in patients with better outcome, suggesting a neuroprotective role of IGF-I. Accurate evaluation and long-term follow-up of all patients with stroke are necessary to define the prevalence of hypopituitarism, and its relationship with type, severity, and outcome from stroke. Discovery and adequate treatment of possible endocrine deficiencies may improve outcome and quality of life of patients with stroke. |
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Authors:
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M Bondanelli; M R Ambrosio; M C Zatelli; N Basaglia; E C Degli Uberti |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 31 ISSN: 0391-4097 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2009-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: 16-20 Citation Subset: IM |
Affiliation:
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Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, 44100 Ferrara, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebrovascular Disorders
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complications,
epidemiology* Follow-Up Studies Humans Hypopituitarism / complications, epidemiology*, etiology Pituitary Gland / physiopathology Prevalence Stroke / complications, epidemiology, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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