Document Detail

Prevalence of hypopituitarism in patients with cerebrovascular diseases.
MedLine Citation:
PMID:  19020380     Owner:  NLM     Status:  MEDLINE    
Stroke is one of the main causes of death and disability in the adult population. Changes in pituitary hormone secretion may be observed during the acute phase of stroke, representing part of the adaptive response to injury. However, reduced pituitary hormone secretion, caused by pituitary and/or hypothalamus damage, may also occur. Hypopituitarism has been observed in 19% of patients with ischemic stroke and 47% of patients with subarachnoid hemorrhage, presenting as an isolated deficiency in most cases. Diabetes insipidus is very rare. Low IGF-I levels, during the acute phase of stroke, have been associated with poor outcome and high mortality. During rehabilitation, higher IGF-I levels have been observed in patients with better outcome, suggesting a neuroprotective role of IGF-I. Accurate evaluation and long-term follow-up of all patients with stroke are necessary to define the prevalence of hypopituitarism, and its relationship with type, severity, and outcome from stroke. Discovery and adequate treatment of possible endocrine deficiencies may improve outcome and quality of life of patients with stroke.
M Bondanelli; M R Ambrosio; M C Zatelli; N Basaglia; E C Degli Uberti
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  31     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  16-20     Citation Subset:  IM    
Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, 44100 Ferrara, Italy.
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MeSH Terms
Cerebrovascular Disorders / complications,  epidemiology*
Follow-Up Studies
Hypopituitarism / complications,  epidemiology*,  etiology
Pituitary Gland / physiopathology
Stroke / complications,  epidemiology,  physiopathology

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