Document Detail

Prevalence of hyperhomocysteinemia in an elderly population.
MedLine Citation:
PMID:  12022240     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Currently, total hyperhomocysteinemia (tHHcy) is a well-known condition linked to a higher risk of vascular disease. Prevalence of HHcy increases in elderly persons as the risk associated with it persists. Because factors can be potentially reduced in the elderly, it is important to carry out epidemiologic studies of HHcy. PROCEDURE: Previously we described the prevalence of hypertension control in an elder population; now, in an observational cross-sectional simple blind study, total homocysteine (tHcy) concentration was determined in 196 of 400 patients from the original cohort. RESULTS: Mean Hcy concentration was 13.2 ,amol/L (95% confidence interval 12.4-14.0; range, 5.0 to 48.9); 15.0 ,imol/L for men and 12.3 pAmol/L for women. Mean serum folic acid levels were 4.9 + 3.1 ng/mL (range, 2.0 to 20.0 ng/mL), and vitamin B12 levels were 384.8 314.1 pg/mL (range, 48.0 to 1500.0 pg/mL). Taking into account the reference values established by the Third National Health and Nutrition Examination Survey III study, HHcy was detected in 69.8% of all the subjects evaluated. The study showed that 76.2% of the men and 66.4% of the women had high Hcy levels. CONCLUSIONS: The very high prevalence of tHHcy in the elderly population, and the consequent risks associated with it suggest that although there are no trials that effectively prove the benefit of tHcy decrease, nutritional intervention is still justified.
Jorge J Janson; Carlos R Galarza; Alicia Murúa; Irene Quintana; Pablo A Przygoda; Gabriel Waisman; Luis Camera; Lucia Kordich; Margarita Morales; Luis M Mayorga; Mario I Camera
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  15     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-22     Completed Date:  2002-11-08     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  394-7     Citation Subset:  IM    
Sociedad Argentina de Medicina Vascular, and Hospital Italiano de Buenos Aires, Argentina.
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MeSH Terms
Age Distribution
Aged, 80 and over
Cohort Studies
Cross-Sectional Studies
Folic Acid / blood
Homocysteine / blood
Hyperhomocysteinemia / blood,  epidemiology*
Sex Distribution
Vitamin B 12 / blood
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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