Document Detail


Prevalence of hepatobiliary dysfunction in patients with ulcerative colitis.
MedLine Citation:
PMID:  7733609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to estimate the prevalence of hepatobiliary dysfunction in a regional unselected group of ulcerative colitis (UC) patients. Five hundred and thirty-four patients were included in this study. Eighty-one per cent of them had never had abnormal alkaline phosphatase (ALP) values and 72% no abnormal alanine amino-transferase (ALAT) values. Thirty patients (6%) had had ALP values more than twice the normal (> 550 U/L) at least once during their disease. Furthermore, 24 (34%) out of 70 patients with routine liver biopsy at colectomy had changes in their liver histology, 13 (19%) of these also having ALP and ALAT values within normal range. Primary sclerosing cholangitis (PSC) had been diagnosed in 11 (2%) patients. All but one of the PSC patients had had ALP and ALAT values more than twice the normal. Almost 30% of all patients had had abnormalities in their liver biochemistry at least once during their disease. Normal liver biochemistry did not seem to exclude changes in liver histology. Although minor hepatobiliary dysfunction is common in patients with UC, more serious conditions such as PSC were found to occur in only 2% of patients.
Authors:
P Aitola; A L Karvonen; M Matikainen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annales chirurgiae et gynaecologiae     Volume:  83     ISSN:  0355-9521     ISO Abbreviation:  Ann Chir Gynaecol     Publication Date:  1994  
Date Detail:
Created Date:  1995-05-30     Completed Date:  1995-05-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7609767     Medline TA:  Ann Chir Gynaecol     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  275-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, Tampere University Hospital, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Alanine Transaminase / blood
Alkaline Phosphatase / blood
Aspartate Aminotransferases / blood
Biopsy
Cholangiopancreatography, Endoscopic Retrograde
Cholangitis, Sclerosing / diagnosis*,  enzymology,  pathology
Colectomy
Colitis, Ulcerative / diagnosis*,  enzymology,  pathology,  surgery
Female
Follow-Up Studies
Humans
Liver / pathology
Liver Diseases / diagnosis*,  enzymology,  pathology
Liver Function Tests*
Male
Middle Aged
Postoperative Complications / diagnosis,  enzymology,  pathology
Chemical
Reg. No./Substance:
EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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