| Prevalence of hepatitis E virus infection in liver transplant recipients. | |
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MedLine Citation:
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PMID: 19790147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatitis E virus (HEV) infection is known to run a self-limited course. Recently, chronic hepatitis E has been described in several immunosuppressed patients after solid organ transplantation. The prevalence of HEV infection after transplantation, however, is unknown. We studied HEV parameters [HEV RNA, HEV immunoglobulin M (IgM), and HEV immunoglobulin G (IgG) by enzyme-linked immunosorbent assay and confirmatory immunoblotting] in a cohort of 285 adult liver transplant recipients. The most recent freeze-stored sera were investigated, and if they were positive, a retrospective analysis was performed. Samples from 274 patients (96.1%) tested negative for all HEV parameters. This included a patient described earlier as having experienced an episode of chronic HEV hepatitis in the past. One patient was found positive for HEV RNA without HEV antibodies. She presently suffers from chronic HEV hepatitis and has also been described before. Sera from 9 patients tested positive for HEV IgG without HEV IgM or HEV RNA. Six of these 9 patients (2.1% of the total) were found to have HEV IgG antibodies in retrospect related to an HEV infection at some time pre-transplant as they also tested positive in a pretransplant serum sample. One of these 9 patients suffered in retrospect from a chronic HEV infection with mild hepatitis between 2 and 5 years after liver transplantation on the basis of the course of HEV RNA, IgM, and IgG, aminotransferases, and liver histology. Overall, the prevalence of acquired HEV hepatitis after liver transplantation was 1% in this cohort. We conclude that liver transplant recipients have a risk for chronic HEV infection, but the prevalence is low. |
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Authors:
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Elizabeth B Haagsma; Hubert G M Niesters; Arie P van den Berg; Annelies Riezebos-Brilman; Robert J Porte; Harry Vennema; Johan H J Reimerink; Marion P G Koopmans |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society Volume: 15 ISSN: 1527-6473 ISO Abbreviation: Liver Transpl. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2009-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100909185 Medline TA: Liver Transpl Country: United States |
Other Details:
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Languages: eng Pagination: 1225-8 Citation Subset: IM |
Copyright Information:
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Copyright 2009 AASLD |
Affiliation:
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Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. e.b.haagsma@int.umcg.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cohort Studies Enzyme-Linked Immunosorbent Assay / methods Female Hepatitis E / complications*, epidemiology*, virology Hepatitis E virus / metabolism* Humans Immunoglobulin G / metabolism Immunoglobulin M / metabolism Liver Diseases / complications*, epidemiology*, virology Liver Transplantation / methods* Male Middle Aged Prevalence RNA, Viral / metabolism Retrospective Studies Risk |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G; 0/Immunoglobulin M; 0/RNA, Viral |
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