Document Detail


Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parameters.
MedLine Citation:
PMID:  16410926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of the present study was to analyze HCV serological and virological parameters from hemophiliacs in the State of Bahia. Anti-HCV was investigated by ELISA in a cohort of 268 hemophiliacs A/B who were followed-up in a reference unit for hemotherapy in the State of Bahia. HCV viremia and genotypes were also determined from a subset of 66 anti-HCV seropositive hemophiliacs. Seroprevalence among hemophiliacs was 42.2% (95% CI 36.5-48.1) and was significantly higher (p<0.05) according to age > or =10 years, presence of factor VIII/IX inhibitory antibodies and other infection markers. None of the hemophiliacs less than 5 years of age were anti-HCV seropositive. Viremia was detectable in 77.3% (51/66). HCV genotype 1 (74%) was the most prevalent followed by genotype 3 (22%) and genotype 2 (4%). Our results indicate that HCV prevalence is still high among hemophiliacs, although HCV transmission was not observed in young hemophiliacs.
Authors:
Luciano Kalabric Silva; Maria Betânia Souza da Silva; Gisele Barreto Lopes; Itatiana Ferreira Rodart; Fernando Quadros Costa; Nelma P Santana; Raymundo Paraná; Aurelino Santana; Mitermayer Galvão dos Reis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-04
Journal Detail:
Title:  Revista da Sociedade Brasileira de Medicina Tropical     Volume:  38     ISSN:  0037-8682     ISO Abbreviation:  Rev. Soc. Bras. Med. Trop.     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2006-01-13     Completed Date:  2006-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7507456     Medline TA:  Rev Soc Bras Med Trop     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  496-502     Citation Subset:  IM    
Affiliation:
Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Research Center, Fundação Oswaldo Cruz, Salvador, BA, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Biological Markers / blood
Blood Coagulation Factors / immunology
Brazil / epidemiology
Child
Child, Preschool
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Hemophilia A / blood,  virology*
Hemophilia B / blood,  virology*
Hepacivirus / genetics,  immunology*
Hepatitis C / diagnosis,  epidemiology*,  virology
Hepatitis C Antibodies / blood*
Humans
Infant
Male
Middle Aged
Prevalence
Risk Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Coagulation Factors; 0/Hepatitis C Antibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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