Document Detail


Prevalence of hepatitis C virus genotypes in southern Italy.
MedLine Citation:
PMID:  9062779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HCV is ubiquitous. In 50% of all cases it causes chronic hepatitis that often evolves into liver cirrhosis and hepatocellular carcinoma. Recently HCV has been classified in 5 genotypes by Okamoto. The purpose of this study is to evaluate the prevalence of 5 genotypes in Campania, a region of southern Italy, where the prevalence of anti-HCV antibodies ranges from 0.87 to 4%, and to evaluate the correlation between the HCV genotypes and the severity of histological damage. One-hundred- and-thirty-five anti-HCV positive patients were enrolled and tested by PCR to identify HCV-RNA. One-hundred-and-twenty-four patients resulted HCV-RNA positive. Genotyping was performed as described by Okamoto et al. with minor modifications of the specific primer to type III proposed by Silini et al. Eight patients were negative for all genotypes. Eight patients were positive for type I(1a), 61 for type II(1b), 39 for type III(2a), 11 for type IV(2b) and 1 for type V(3a). In 4 cases two different genotypes were present in the same sample [II(1b)-IV(2b), III(2a)-II(1b) twice, III (2a)-IV(2b)]. Histological evaluation of liver damage showed: CPH (22 cases), minimal CAH (56), severe CAH (31) and liver cirrhosis (15). There was no statistically significant correlation between the 5 genotypes and the severity of histological damage. Data on the prevalence of genotype II (1b) in Italy are similar to those reported for other European countries. The prevalence of genotypes in southern Italy is similar to that reported in the population of northern Italy.
Authors:
S Cicciarello; G Borgia; J Crowell; R Ciampi; R Cerini; R Orlando; M Mainolfi; L Reynaud; M Milano; M Piazza
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of epidemiology     Volume:  13     ISSN:  0393-2990     ISO Abbreviation:  Eur. J. Epidemiol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-13     Completed Date:  1997-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508062     Medline TA:  Eur J Epidemiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
Affiliation:
Institute of Infectious Diseases, University of Naples Federico II, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Genotype
Hepacivirus / genetics*
Hepatitis C / epidemiology*,  physiopathology
Humans
Italy / epidemiology
Male
Middle Aged
Polymerase Chain Reaction
Prevalence
RNA, Viral / analysis*
Chemical
Reg. No./Substance:
0/RNA, Viral

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