Document Detail

Prevalence of hepatitis B virus infection in a highly endemic area of southern China after catch-up immunization.
MedLine Citation:
PMID:  22499009     Owner:  NLM     Status:  In-Data-Review    
The Chinese national goals for control of hepatitis B virus (HBV) infection were to achieve a prevalence of HBsAg below 7% for the entire population, and 1% for children under 5-year old, by 2010. To determine whether Guangxi, a multi-minority province with a low socio-economic status and a very high prevalence of HBV, achieved this goal, a seroepidemiological survey of HBV infection was carried out using stratified, random cluster sampling. The results show that the overall prevalence of HBsAg is 9.16% [95% confidence interval (CI) = 8.32-10%]. The prevalence in males (10.96%, 95% CI = 9.64-12.28%) is significantly higher than in females (7.71%, 95% CI = 6.64-8.78%; χ(2)  = 10.5923, P < 0.05). The prevalence in children under 5-year old is 3.62% (95% CI = 0.60-6.64%) and increases with age. The prevalence of HBsAg in non-immunized individuals is significantly higher than in those immunized completely, although not within 24 hr of birth (χ(2)  = 31.426, P < 0.05); a significant difference was found in those below the age of 20 years but not in older persons. Gender, age, immunization history, and familial HBsAg carriers are risk factors for infection. In conclusion, this study indicates that Guangxi has not reached the goal for the control of HBV infection. Catch-up HBV immunization may not protect adults effectively against infection in highly endemic regions. J. Med. Virol. 84:878-884, 2012. © 2012 Wiley Periodicals, Inc.
Zhong-Liao Fang; Tim J Harrison; Jin-Ye Yang; Qin-Yan Chen; Xue-Yan Wang; Jian-Jun Mo
Related Documents :
23173749 - A new treatment for neurogenic inflammation caused by ev71 with cr2-targeted complement...
24808249 - Neglected parasitic infections in the united states: toxocariasis.
22429689 - Lobomycosis: an emerging disease in humans and delphinidae.
24475559 - Antibacterial resistance: an overview.
22905059 - A rare case of seronegative culture--proven infection with brucella suis.
22426109 - Use of mouse models to study the variability in virulence associated with specific geno...
17953479 - A virtual look at epstein-barr virus infection: biological interpretations.
21765079 - Racial differences in tuberculosis infection in united states communities: the coronary...
9468099 - Activation of epithelial cells in gastritis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical virology     Volume:  84     ISSN:  1096-9071     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  878-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Nanning, Guangxi, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hepatitis B virus X protein blocks filamentous actin bundles by interaction with eukaryotic translat...
Next Document:  Assessing risk of a short-term antiretroviral therapy discontinuation as a read-out of viral control...