| Prevalence of hepatitis B virus infection in a highly endemic area of southern China after catch-up immunization. | |
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MedLine Citation:
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PMID: 22499009 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The Chinese national goals for control of hepatitis B virus (HBV) infection were to achieve a prevalence of HBsAg below 7% for the entire population, and 1% for children under 5-year old, by 2010. To determine whether Guangxi, a multi-minority province with a low socio-economic status and a very high prevalence of HBV, achieved this goal, a seroepidemiological survey of HBV infection was carried out using stratified, random cluster sampling. The results show that the overall prevalence of HBsAg is 9.16% [95% confidence interval (CI) = 8.32-10%]. The prevalence in males (10.96%, 95% CI = 9.64-12.28%) is significantly higher than in females (7.71%, 95% CI = 6.64-8.78%; χ(2) = 10.5923, P < 0.05). The prevalence in children under 5-year old is 3.62% (95% CI = 0.60-6.64%) and increases with age. The prevalence of HBsAg in non-immunized individuals is significantly higher than in those immunized completely, although not within 24 hr of birth (χ(2) = 31.426, P < 0.05); a significant difference was found in those below the age of 20 years but not in older persons. Gender, age, immunization history, and familial HBsAg carriers are risk factors for infection. In conclusion, this study indicates that Guangxi has not reached the goal for the control of HBV infection. Catch-up HBV immunization may not protect adults effectively against infection in highly endemic regions. J. Med. Virol. 84:878-884, 2012. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Zhong-Liao Fang; Tim J Harrison; Jin-Ye Yang; Qin-Yan Chen; Xue-Yan Wang; Jian-Jun Mo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medical virology Volume: 84 ISSN: 1096-9071 ISO Abbreviation: J. Med. Virol. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-04-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705876 Medline TA: J Med Virol Country: United States |
Other Details:
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Languages: eng Pagination: 878-84 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Nanning, Guangxi, China. zhongliaofang@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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