Document Detail


Prevalence of hepatitis B and C seropositivity in a Nigerian cohort of HIV-infected patients.
MedLine Citation:
PMID:  18626434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The clinical and public health implications of the convergence of the human immunodeficiency virus (HIV) epidemic and chronic viral hepatitis in sub-Saharan Africa are poorly understood. This study was designed to determine the seroprevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV), and the impact of co-infection on baseline serum alanine transaminase (ALT), CD4+ T lymphocyte (CD4) count, and plasma HIV-RNA (viral load) in a cohort of HIV-infected Nigerians.
METHODS: A retrospective study was conducted, on eligible treatment-naive patients who presented between August 2004 and February 2007 to the University College Hospital (UCH), Ibadan, Nigeria. Demographic data and pre-treatment laboratory results (hepatitis B surface antigen (HBsAg), HCV antibodies (anti-HCV), ALT, CD4 count and viral load) were retrieved from the medical records. Fisher's exact, two sample t-tests, and the Wilcoxon rank sum tests were used to compare groups. A logistic regression model was fitted to explore characteristics associated with co-infection status.
RESULTS: A total of 1779 HIV-infected patients (male: female ratio, 1:2) met inclusion criteria. HBsAg was present in 11.9%, anti-HCV in 4.8% and both markers in 1%. HBsAg was more common among males than females (15.4% vs 10.1%, respectively p = 0.001) while anti-HCV was detected in a similar proportion of males and females (5.3% versus 4.6%, respectively p = 0.559). HIV-infected patients with anti-HCV alone had a lower mean baseline CD4 count compared to those without anti-HCV or HBsAg (197 cells/mm3 vs 247 cells/mm3, respectively p = 0.008). Serum ALT was higher among patients with HBsAg compared to those without HBsAg or anti-HCV (43 International Units (IU) vs. 39 IU, respectively p = 0.015). Male gender was associated with HBV co-infection on logistic regression (OR1.786; 95% CI, 1.306-2.443; p < 0.005).
CONCLUSION: More HIV-infected females than males presented for care in this cohort. We identified a relatively high prevalence of HBV and HCV co-infection in general, and a higher rate of HBV co-infection among males than females. Pre-treatment CD4 count was significantly lower among those with HCV co-infection, while ALT was slightly higher among those with HBV co-infection. Triple infection with HIV, HBV and HCV was present in a small but significant proportion of patients. These findings underscore the importance of testing for HBV and HCV in all HIV-infected persons in our setting.
Authors:
Jesse A Otegbayo; Babafemi O Taiwo; Titilola S Akingbola; Georgina N Odaibo; Kayode S Adedapo; Sudhir Penugonda; Isaac F Adewole; David O Olaleye; Rob Murphy; Phyllis Kanki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of hepatology     Volume:  7     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2008 Apr-Jun
Date Detail:
Created Date:  2008-07-15     Completed Date:  2008-11-25     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  152-6     Citation Subset:  IM    
Affiliation:
Departments of Medicine, Gastrointestinal/Liver Unit, University College Hospital, Ibadan, Nigeria. otegbayoa@comui.edu.ng.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alanine Transaminase / blood
CD4 Lymphocyte Count
Cohort Studies
Female
HIV Infections / blood,  complications*,  epidemiology*
Hepatitis B / blood,  complications*,  epidemiology*
Hepatitis C / blood,  complications*,  epidemiology*
Humans
Male
Nigeria / epidemiology
Retrospective Studies
Seroepidemiologic Studies
Viral Load
Chemical
Reg. No./Substance:
EC 2.6.1.2/Alanine Transaminase

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