Document Detail


Prevalence of genotypic drug resistance among a cohort of HIV-infected newborns.
MedLine Citation:
PMID:  12626889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A retrospective, blinded study was conducted to examine the prevalence of antiretroviral drug resistance among a cohort of HIV-infected infants born in 1998 and 1999 in New York State. The earliest available HIV-positive specimen was tested. Most samples were from infants younger than 60 days of age. Genotype data were generated for the protease and reverse transcriptase genes of HIV-1 proviral DNA from 91 infected infants. Eleven infants (12.1%) had provirus with mutations associated with drug resistance, with all three classes of antiretroviral drugs represented. Two infants (2.2%) had mutations associated with resistance to two classes of antiretrovirals. Perinatal antiretroviral drug exposure was examined; it was not found to be significantly associated with the presence of resistance mutations. However, for those infants who had perinatal antiretroviral exposure and genotypic evidence of drug resistance to HIV, the mutations that were detected correlated with at least one antiretroviral from the perinatal period. The prevalence of genotypic drug resistance among this infant cohort is comparable with that found among recently infected adults. These results suggest that resistance testing should be strongly considered for perinatally infected infants, at the earliest possible time point, to avoid use of antiretroviral drugs to which the infant has preexisting resistance.
Authors:
Monica M Parker; Nancy Wade; Robert M Lloyd; Guthrie S Birkhead; Brian K Gallagher; Babu Cheku; Timothy Sullivan; Jill Taylor
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  32     ISSN:  1525-4135     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-10     Completed Date:  2003-04-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-7     Citation Subset:  IM; X    
Affiliation:
Wadsworth Center, New York State Department of Health, Albany, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-HIV Agents / therapeutic use*
Cohort Studies
DNA, Viral / genetics
Drug Resistance, Viral / genetics
Female
Genotype
HIV Infections / drug therapy*,  epidemiology,  genetics
HIV Protease / genetics
HIV Reverse Transcriptase / genetics
HIV-1 / drug effects*,  genetics
Humans
Infant
Infant, Newborn
Male
New York / epidemiology
Perinatal Care
Proviruses / genetics
Retrospective Studies
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/DNA, Viral; EC 2.7.7.49/HIV Reverse Transcriptase; EC 3.4.23.-/HIV Protease

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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