| Prevalence and genotype distribution of human papillomavirus infection of the cervix in Spain: The CLEOPATRE study. | |
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MedLine Citation:
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PMID: 22499018 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Human papillomavirus (HPV) infection is a necessary cause of cervical cancer. The aim of this study was to estimate the prevalence of cervical HPV infection and HPV type-specific distribution among women attending cervical cancer screening in Spain during 2007 and 2008. Women aged 18-65 years were recruited according to an age-stratified sampling method. Liquid-based cervical samples were collected and analyzed for cytology, HPV detection, and genotyping. HPV genotyping was determined using the INNO-LiPA HPV Genotyping Extra Reverse Hybridization Line Probe Assay. Prevalence estimates were age-standardized using 2001 Spanish census data. The present study included 3,261 women. Age-standardized HC2-based HPV prevalence was 14.3% (95% CI, 13.1-15.5) among women aged 18-65 years, and 28.8% (26.6-31.1) among women aged 18-25 years. High-risk HPV types were detected in 12.2% (95% CI, 11.1-13.4) of HPV-tested women, representing 84.0% of HPV-positive samples. Multiple infections were present in 4.1% (95% CI, 3.4-4.8) of HPV-tested women (25.0% of HPV-positive samples). The most common high-risk HPV-types among HPV-tested women were 16 (2.9%), 52 (1.8%), 51 (1.6%), 31 (1.3%), and 66 (1.2%). HPV-type 16 was present in 16.9% of HPV-positive samples. One or more of the HPV vaccine types 6/11/16/18 were detected in 3.8% of HPV-tested women (22.1% of HPV-positive samples). Though not a true population-based survey, this study provides valuable baseline data for future assessment of the impact of current HPV vaccination programs in Spain. The high prevalence of HPV infection among young women may reflect recent changes in sexual behavior. J. Med. Virol. 84:947-956, 2012. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Xavier Castellsagué; Thomas Iftner; Esther Roura; José Antonio Vidart; Susanne K Kjaer; F Xavier Bosch; Nubia Muñoz; Santiago Palacios; Maria San Martin Rodriguez; Laurence Serradell; Laurence Torcel-Pagnon; Javier Cortes; |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Journal of medical virology Volume: 84 ISSN: 1096-9071 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-4-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705876 Medline TA: J Med Virol Country: - |
Other Details:
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Languages: ENG Pagination: 947-956 Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Spain. xcastellsague@iconcologia.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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